K Athira, Kumar B Siva, Reddy S Giridhar, Prashanthi K, Kugabalasooriar Sanga, Posa Jyothi Kumari
Department of Physical Sciences, Amrita School of Engineering, Bengaluru, Amrita Vishwa Vidyapeetham, 560035, India.
Department of Biotechnology, Ramaiah University of Applied Sciences, Bengaluru, 560054, India.
Heliyon. 2024 Nov 19;10(23):e40547. doi: 10.1016/j.heliyon.2024.e40547. eCollection 2024 Dec 15.
Levodopa (LD), a precursor to dopamine, is commonly used to treat Parkinson's disease. However, its oral formulations suffer from low bioavailability, toxicity, and untargeted delivery. This study aimed to develop a nature-based hydrogel for sustained LD release, addressing these limitations. The hydrogel was synthesized using sodium alginate (SAl) and lignosulfonic acid (LSA) as polymers, cross-linked with Ba ions, and coated with iron oxide nanoparticles (FeO) and graphene oxide nanoparticles (GO). The resulting ligno-alginate films were characterized by Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Thermogravimetric Analysis (TGA), and Field Emission Scanning Electron Microscopy (FESEM). drug release was evaluated using UV-visible spectroscopy. The formulations LD 2 (SAl-LSA-GO-LD) and LD 3 (SAl-LSA-FeO-GO-LD) demonstrated superior sustained release properties, attributed to the hydrophobic layer provided by GO, which controlled the swelling rate and slowed drug diffusion. LD 2 showed the highest drug loading efficiency at 69 % and a sustained release of 24 % over 48 h, which was better than previously reported work of 64 % in 30 h. Incorporating FeO endowed the delivery vehicle with magnetic properties for targeted drug delivery. This study presents a novel and efficient approach for the sustained release of LD using a ligno-alginate hydrogel coated with FeO and GO, offering promising potential for Parkinson's treatment.
左旋多巴（LD）是多巴胺的前体，常用于治疗帕金森病。然而，其口服制剂存在生物利用度低、毒性和非靶向递送等问题。本研究旨在开发一种基于天然材料的水凝胶用于左旋多巴的持续释放，以解决这些局限性。该水凝胶以海藻酸钠（SAl）和木质素磺酸（LSA）为聚合物合成，用钡离子交联，并包覆氧化铁纳米颗粒（FeO）和氧化石墨烯纳米颗粒（GO）。所得木质素-海藻酸盐薄膜通过傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）、热重分析（TGA）和场发射扫描电子显微镜（FESEM）进行表征。药物释放通过紫外-可见光谱进行评估。制剂LD 2（SAl-LSA-GO-LD）和LD 3（SAl-LSA-FeO-GO-LD）表现出优异的持续释放性能，这归因于GO提供的疏水层，其控制了溶胀速率并减缓了药物扩散。LD 2显示出最高的载药效率，为69%，在48小时内持续释放24%，优于先前报道的在30小时内释放64%的研究成果。加入FeO使递送载体具有磁性以实现靶向药物递送。本研究提出了一种使用包覆有FeO和GO的木质素-海藻酸盐水凝胶实现左旋多巴持续释放的新颖且有效的方法，为帕金森病的治疗提供了有前景的潜力。
