Zhu Linyun, Ni Zhenhua, Luo Xuming, Zhang Zhuhua, Wang Shiqiang, Meng Ziyu, Gu Xiandong, Wang Xiongbiao
Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai.
Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Int J Chron Obstruct Pulmon Dis. 2018 Feb 21;13:645-652. doi: 10.2147/COPD.S157084. eCollection 2018.
Chronic bronchitis is thought to occur in elderly patients, and smoking seems to be an important risk factor. The outcomes related to the age of onset in patients with chronic bronchitis are still unclear.
A retrospective study was conducted on deceased patients whose diagnosis included bronchitis from 2010 to 2016. Patients were separated into two groups according to the age of onset (Group I, age ≤50 years old; Group II, age >50 years old). Information regarding disease course, smoking history, death age, number of admissions per year, Hugh Jones Index, and self-reported comorbidities of the patients was recorded.
The courses of chronic cough and sputum were 33.38±7.73 years and 14.44±8.60 years in Group I and Group II, respectively (<0.05). The death ages of Group I and Group II were 77.65±7.87 years and 84.69±6.67 years, respectively (<0.05). There was a significant negative correlation between the number of hospital admissions per year and the age of onset. The age of onset was negatively associated with daily smoking count (=-0.210) and total smoking count (=-0.146). In Group I, there were fewer cases of coronary heart disease (OR =0.41 [0.24-0.71]), neurological diseases (OR =0.48 [0.24-0.97]), and total comorbidities (OR =0.67 [0.54-0.85]) than in Group II.
Patients with early onset chronic bronchitis had a longer history, younger death age, poorer health status, and lower incidence of comorbidities.
慢性支气管炎被认为多见于老年患者，吸烟似乎是一个重要的危险因素。慢性支气管炎患者发病年龄相关的预后仍不明确。
对2010年至2016年诊断包括支气管炎的已故患者进行回顾性研究。根据发病年龄将患者分为两组（第一组，年龄≤50岁；第二组，年龄>50岁）。记录患者的病程、吸烟史死亡年龄、每年住院次数、休·琼斯指数以及自我报告的合并症情况。
第一组和第二组慢性咳嗽和咳痰的病程分别为33.38±7.73年和14.44±8.60年（<0.05）。第一组和第二组的死亡年龄分别为77.65±7.87岁和84.69±6.67岁（<0.05）。每年住院次数与发病年龄之间存在显著负相关。发病年龄与每日吸烟量（=-0.210）和总吸烟量（=-0.146）呈负相关。与第二组相比，第一组冠心病（OR =0.41 [0.24 - 0.71]）、神经系统疾病（OR =0.48 [0.24 - 0.97]）及合并症总数（OR =0.67 [0.54 - 0.85]）的病例较少。
早发型慢性支气管炎患者病程较长、死亡年龄较轻、健康状况较差且合并症发生率较低。
