Baumler Stephen M, McHale Andrew M, Blanchard G J
Michigan State University, Department of Chemistry, 578 S. Shaw Lane, East Lansing, MI 48824.
J Electroanal Chem (Lausanne). 2018 Mar 1;812:159-165. doi: 10.1016/j.jelechem.2017.11.029. Epub 2017 Nov 11.
Understanding the thermodynamics and kinetics of interactions between model lipid bilayers and planar supports is of critical importance in the furtherance of biosensing and the creation of biomimetic devices. Evaluating these properties can be accomplished through understanding the diffusional properties of the bilayer constituents. In this report, the dynamics of a model DMPC bilayer supported on a phosphorylated silica surface are studied in the presence and absence of interfacial Ca as a function of pH of the aqueous overlayer. The data for this system reveal the importance of the balance of ionic interactions between the interfacial species, and the dependence of the diffusional, kinetic and thermodynamic properties of the system on pH. The thermodynamic data suggest that interactions between the bilayer and surface are mediated enthalpically rather than entropically.
了解模型脂质双层与平面支撑物之间相互作用的热力学和动力学，对于推动生物传感和仿生装置的创建至关重要。通过了解双层成分的扩散特性可以评估这些性质。在本报告中，研究了在有无界面Ca的情况下，支撑在磷酸化二氧化硅表面的模型DMPC双层的动力学，该动力学是水相上层pH值的函数。该系统的数据揭示了界面物种之间离子相互作用平衡的重要性，以及系统的扩散、动力学和热力学性质对pH值的依赖性。热力学数据表明，双层与表面之间的相互作用是由焓介导的，而非熵。
