Gelaw Yeshigeta, Shoukry Shoeib Mohamed, Othman Ihab Saad
Department of Ophthalmology, College of Health Sciences, Jimma University, Jimma, Ethiopia.
Eye and Laser World Hospital, Giza, Egypt.
Am J Ophthalmol Case Rep. 2016 Dec 28;5:130-133. doi: 10.1016/j.ajoc.2016.12.013. eCollection 2017 Apr.
To report a patient who presented with a very late-onset new growth of intraocular retinoblastoma, which occurred 11 years after the initial combined treatment.
A 12-year-old monoophthalmic female patient presented with bilateral familial retinoblastoma showing new growth of intraocular tumor after 11 years of complete regression following combined local and systemic treatments. The new tumor growth was treated with diode laser transpupillary thermotherapy, ruthenium-106 plaque radiotherapy and adjuvant intravenous chemotherapy and the tumor regressed.
Despite initial satisfactory treatment and complete regression of the tumor, very late-onset new growth of intraocular retinoblastoma can occur. Hence, life-long follow-up in all patients with retinoblastoma is warranted, given the risk for new tumor formation even later in life. To our knowledge, this is the first report of new growth of intraocular retinoblastoma after regression for more than a decade.
报告一名患者，其眼内视网膜母细胞瘤出现非常晚发的新生长，发生在初始联合治疗11年后。
一名12岁单眼女性患者，患有双侧家族性视网膜母细胞瘤，在局部和全身联合治疗后完全消退11年后出现眼内肿瘤新生长。新的肿瘤生长采用二极管激光经瞳孔温热疗法、钌106敷贴放射疗法和辅助静脉化疗进行治疗，肿瘤消退。
尽管初始治疗效果满意且肿瘤完全消退，但眼内视网膜母细胞瘤仍可出现非常晚发的新生长。因此，鉴于即使在生命后期仍有新肿瘤形成的风险，所有视网膜母细胞瘤患者都需要终身随访。据我们所知，这是首次报告视网膜母细胞瘤消退十多年后出现眼内肿瘤新生长。
