Mahmoudian-Sani Mohammad-Reza, Rafeei Fatemeh, Amini Razieh, Saidijam Massoud
Department of Genetics and Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
J Cosmet Dermatol. 2018 Oct;17(5):650-659. doi: 10.1111/jocd.12512. Epub 2018 Mar 4.
Mesenchymal stem cells (MSCs) are multipotent stem cells that have the potential of proliferation, high self-renewal, and the potential of multilineage differentiation. The differentiation potential of the MSCs in vivo and in vitro has caused these cells to be regarded as potentially appropriate tools for wound healing. After the burn, trauma or removal of the tumor of wide wounds is developed. Although standard treatment for skin wounds is primary healing or skin grafting, they are not always practical mainly because of limited autologous skin grafting.
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For clinical use of the MSCs in wound healing, two key issues should be taken into account: First, engineering biocompatible scaffolds clinical use of which leads to the least amount of side effects without any immunologic response and secondly, use of stem cells secretions with the least amount of clinical complications despite their high capability of healing damage.
In light of the MSCs' high capability of proliferation and multilineage differentiation as well as their significant role in modulating immunity, these cells can be used in combination with tissue engineering techniques. Moreover, the MSCs' secretions can be used in cell therapy to heal many types of wounds. The combination of MSCs and PRP aids wound healing which could potentially be used to promote wound healing.
间充质干细胞（MSCs）是多能干细胞，具有增殖、高度自我更新以及多向分化的潜力。MSCs在体内和体外的分化潜力使这些细胞被视为伤口愈合的潜在合适工具。烧伤、创伤或广泛伤口肿瘤切除后会出现这种情况。尽管皮肤伤口的标准治疗方法是一期愈合或皮肤移植，但它们并不总是可行的，主要原因是自体皮肤移植有限。
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对于MSCs在伤口愈合中的临床应用，应考虑两个关键问题：第一，工程化生物相容性支架的临床应用，其副作用最少且无任何免疫反应；第二，使用干细胞分泌物，尽管其愈合损伤能力强，但临床并发症最少。
鉴于MSCs具有高增殖和多向分化能力以及在调节免疫方面的重要作用，这些细胞可与组织工程技术联合使用。此外，MSCs的分泌物可用于细胞治疗以愈合多种类型的伤口。MSCs与富血小板血浆（PRP）的联合有助于伤口愈合，这可能潜在地用于促进伤口愈合。
