Lu Jianyu, Zhang Wei, Zhu Yushu, Luo Pengfei, Tong Xirui, Xie Sujie, Jiang Luofeng, Guo Xinya, Huang Jie, Gu Minyi, Ding Xinran, Xian Shuyuan, Huang Runzhi, Ji Shizhao, Xia Zhaofan
Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
Stem Cells Int. 2024 Dec 16;2024:1914585. doi: 10.1155/2024/1914585. eCollection 2024.
Burns are a global public health issue and a major cause of disability and death around the world. Stem cells, which are the undifferentiated cells with the potential for indefinite proliferation and multilineage differentiation, have the ability to replace injured skin and facilitate the wound repair process through paracrine mechanisms. In light of this, the present study aims to conduct a bibliometric analysis in order to identify research hotspots of stem cell-related burns and assess global research tendencies. To achieve this objective, we retrieved scientific publications on burns associated with stem cells covering the period from January 1, 1978, to October 13, 2022, from the Web of Science Core Collection (WoSCC). Bibliometric analyses, including production and collaboration analyses between countries, institutions, authors, and journals, as well as keyword and topic analyses, were conducted using the bibliometrix R package, CiteSpace, and VOSviewer. A total of 1648 burns associated with stem cell documents were published and listed on WOSCC. The most contributive country, institution, journal, and author were the United States, LV Prasad Eye Institute, , and Scheffer C.G. Tseng, respectively. More importantly, combined with historical direct citation network, trend topic analysis, keyword co-occurrence network, and substantial literature analysis, we eventually summarized the research hotspots and frontiers on burns associated stem cell reasearch. The present study obtained deep insight into the developing trends and research hotspots on burns associated with stem cells, which arouses growing concerns and implies increasing clinical implications. The mechanism and therapeutics of epidermal stem cells (ESCs) for burn wounds and the mechanism of mesenchymal stem cells (MSCs) and MSC-derived exosomes for burns wounds are two research hotspots in this field.
烧伤是一个全球性的公共卫生问题，也是世界各地残疾和死亡的主要原因。干细胞是具有无限增殖和多向分化潜能的未分化细胞，能够替代受损皮肤，并通过旁分泌机制促进伤口修复过程。鉴于此，本研究旨在进行文献计量分析，以确定干细胞相关烧伤的研究热点，并评估全球研究趋势。为实现这一目标，我们从科学网核心合集（WoSCC）中检索了1978年1月1日至2022年10月13日期间与干细胞相关的烧伤科学出版物。使用文献计量学R包、CiteSpace和VOSviewer进行文献计量分析，包括国家、机构、作者和期刊之间的产出和合作分析，以及关键词和主题分析。共有1648篇与干细胞相关的烧伤文献发表并列入WOSCC。贡献最大的国家、机构、期刊和作者分别是美国、LV Prasad眼科研究所和谢弗·C·G·曾。更重要的是，结合历史直接引文网络、趋势主题分析、关键词共现网络和大量文献分析，我们最终总结了干细胞相关烧伤研究的热点和前沿。本研究深入洞察了干细胞相关烧伤的发展趋势和研究热点，引起了越来越多的关注，并暗示了越来越大的临床意义。表皮干细胞（ESCs）用于烧伤创面的机制和治疗方法，以及间充质干细胞（MSCs）和MSC衍生外泌体用于烧伤创面的机制是该领域的两个研究热点。
