Brembilla-Perrot B, Taggeddine R, Rebmann J P, Terrier de la Chaise A, Cherrier F, Pernot C
Presse Med. 1987 Jan 31;16(3):103-6.
Ten patients who presented with advanced heart disease and severe ventricular arrhythmia could be considered "at high risk of sudden death" caused by ventricular fibrillation. Yet they died suddenly while under Holter monitoring, and the recordings demonstrated that 4 of these deaths were due to a major disorder of conduction and 6 to ventricular fibrillation. Further analysis of these cases showed that the lethal disturbance of heart rhythm was ascribable to an anti-arrhythmic drug in 5 cases (2 with conduction disorder, 3 with ventricular fibrillation). It would appear that although patients of this kind need anti-arrhythmic drugs, these should be given with caution and in lower doses than in patients with normal left ventricular function.
10例患有晚期心脏病和严重室性心律失常的患者可被视为因心室颤动而“猝死高危”。然而，他们在动态心电图监测期间突然死亡，记录显示其中4例死亡是由于严重传导障碍，6例是由于心室颤动。对这些病例的进一步分析表明，5例（2例传导障碍，3例心室颤动）的致命性心律失常归因于一种抗心律失常药物。看来，尽管这类患者需要抗心律失常药物，但给药时应谨慎，剂量应低于左心室功能正常的患者。
