• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Identification of novel DHFR inhibitors for treatment of tuberculosis by combining virtual screening with in vitro activity assay.

作者信息

Wang Nan, Ren Ji-Xia, Xie Yong

机构信息

a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development , Chinese Academy of Medical Science, Peking Union Medical College , 151 Malianwa North Road, Haidian District, Beijing 100193 , PR China.

b College of Life Science , Liaocheng University , Liaocheng 252059 , PR China.

出版信息

J Biomol Struct Dyn. 2019 Mar;37(4):1054-1061. doi: 10.1080/07391102.2018.1448721. Epub 2018 Apr 6.

DOI:10.1080/07391102.2018.1448721
PMID:29504455
Abstract
摘要

相似文献

1
Identification of novel DHFR inhibitors for treatment of tuberculosis by combining virtual screening with in vitro activity assay.通过虚拟筛选与体外活性测定相结合鉴定用于治疗结核病的新型二氢叶酸还原酶抑制剂。
J Biomol Struct Dyn. 2019 Mar;37(4):1054-1061. doi: 10.1080/07391102.2018.1448721. Epub 2018 Apr 6.
2
Fragment Discovery for the Design of Nitrogen Heterocycles as Mycobacterium tuberculosis Dihydrofolate Reductase Inhibitors.用于设计作为结核分枝杆菌二氢叶酸还原酶抑制剂的含氮杂环片段的发现。
Arch Pharm (Weinheim). 2016 Aug;349(8):602-13. doi: 10.1002/ardp.201600066. Epub 2016 Jun 19.
3
Identification of novel selective Mtb-DHFR inhibitors as antitubercular agents through structure-based computational techniques.通过基于结构的计算技术鉴定新型选择性 Mtb-DHFR 抑制剂作为抗结核药物。
Arch Pharm (Weinheim). 2020 Feb;353(2):e1900287. doi: 10.1002/ardp.201900287. Epub 2019 Dec 23.
4
Preparation, biological evaluation and molecular docking study of imidazolyl dihydropyrimidines as potential Mycobacterium tuberculosis dihydrofolate reductase inhibitors.咪唑基二氢嘧啶作为潜在结核分枝杆菌二氢叶酸还原酶抑制剂的制备、生物学评价及分子对接研究
Bioorg Med Chem Lett. 2016 Aug 15;26(16):4030-5. doi: 10.1016/j.bmcl.2016.06.082. Epub 2016 Jun 28.
5
Interactions of 5-deazapteridine derivatives with Mycobacterium tuberculosis and with human dihydrofolate reductases.5-脱氮蝶啶衍生物与结核分枝杆菌及人二氢叶酸还原酶的相互作用。
J Biomol Struct Dyn. 2004 Oct;22(2):119-30. doi: 10.1080/07391102.2004.10506988.
6
Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase.关联高通量筛选以鉴定结核分枝杆菌二氢叶酸还原酶的作用机制和新型抑制剂。
ACS Chem Biol. 2017 Sep 15;12(9):2448-2456. doi: 10.1021/acschembio.7b00468. Epub 2017 Aug 29.
7
The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling.新型结核分枝杆菌二氢叶酸还原酶抑制剂的鉴定及其结合偏好性的分子模拟研究
Sci Rep. 2015 Oct 16;5:15328. doi: 10.1038/srep15328.
8
Synthesis, molecular docking study and biological evaluation of new pyrrole scaffolds as potential antitubercular agents for dual targeting of enoyl ACP reductase and dihydrofolate reductase.新型吡咯类支架的合成、分子对接研究及作为烯酰基 ACP 还原酶和二氢叶酸还原酶双重靶点的潜在抗结核剂的生物评价。
PLoS One. 2024 May 13;19(5):e0303173. doi: 10.1371/journal.pone.0303173. eCollection 2024.
9
In silico structure-based design of a novel class of potent and selective small peptide inhibitor of Mycobacterium tuberculosis Dihydrofolate reductase, a potential target for anti-TB drug discovery.基于结构的计算机辅助设计新型强效和选择性的结核分枝杆菌二氢叶酸还原酶小分子肽抑制剂，这是抗结核药物发现的一个潜在靶点。
Mol Divers. 2010 Aug;14(3):595-604. doi: 10.1007/s11030-009-9172-6. Epub 2009 Aug 21.
10
Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.结核分枝杆菌Rv2671蛋白作为二氢叶酸还原酶功能类似物对对氨基水杨酸耐药性影响的结构见解
Biochemistry. 2016 Feb 23;55(7):1107-19. doi: 10.1021/acs.biochem.5b00993. Epub 2016 Feb 5.

引用本文的文献

1
Folic acid-sulfonamide conjugates as antibacterial agents: design, synthesis and molecular docking studies.作为抗菌剂的叶酸-磺胺共轭物：设计、合成及分子对接研究
RSC Adv. 2020 Nov 25;10(70):42983-42992. doi: 10.1039/d0ra09051d. eCollection 2020 Nov 23.
2
Discovery of potent Covid-19 main protease inhibitors using integrated drug-repurposing strategy.利用综合药物再利用策略发现有效的新冠病毒主蛋白酶抑制剂。
Biotechnol Appl Biochem. 2021 Aug;68(4):712-725. doi: 10.1002/bab.2159. Epub 2021 Apr 14.