Department of Chemistry , University of Otago , P.O. Box 56, Dunedin , New Zealand.
The New Zealand Institute for Plant & Food Research Limited , Private Bag 4704, Christchurch , New Zealand.
J Nat Prod. 2018 Apr 27;81(4):1116-1120. doi: 10.1021/acs.jnatprod.8b00120. Epub 2018 Mar 5.
Some honeys contain the neurotoxin tutin (1) plus hyenanchin (2), 2-(β-d-glucopyranosyl)tutin (3), and 2-[6'-(α-d-glucopyranosyl)-β-d-glucopyranosyl]tutin (4). These honeys are made by bees collecting honeydew from passionvine hoppers feeding on the sap of tutu plants ( Coriaria spp.). We report a LC-MS study showing that all these picrotoxanes are of plant, not insect, origin. Hyenanchin was barely detectable and the diglucoside was not detectable in C. arborea leaves, but tutu phloem sap contained all four compounds at concentrations up to the highest found in honeydew. It is proposed that the diglucoside may function as a transport form of tutin, analogous to sucrose transport in phloem.
一些蜂蜜中含有神经毒素 tutin（1）、hyenanchin（2）、2-(β-d-吡喃葡萄糖基)tutin（3）和 2-[6'-(α-d-吡喃葡萄糖基)-β-d-吡喃葡萄糖基]tutin（4）。这些蜂蜜是由蜜蜂从吸食 tutu 植物（Coriaria spp.）汁液的 Passion藤叶蝉上采集的蜜露制成的。我们报告了一项 LC-MS 研究，表明所有这些 picrotoxanes 均来自植物，而非昆虫。hyenanchin 的含量可忽略不计，在 C. arborea 叶片中未检测到二糖苷，但 tutu 韧皮部汁液中含有高达在蜜露中发现的最高浓度的所有四种化合物。据推测，二糖苷可能作为 tutin 的运输形式，类似于韧皮部中蔗糖的运输。
