Kinoshita Takeshi, Itaki Nao, Hikita Maho, Aoyagi Yutaka, Hitotsuyanagi Yukio, Takeya Koichi
Faculty of Pharmaceutical Sciences, Teikyo University, 1091-1 Suarashi, Sagamiko-machi, Tsukui-gun, Kanagawa 199-0195, Japan.
Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1040-2. doi: 10.1248/cpb.53.1040.
A new sesquiterpene lactone named coriarin was isolated from achenes (seeds) of Coriaria japonica (Coriariaceae) along with known constituents tutin, dihydrotutin and corianin, and its structure was deduced on a spectroscopic basis. The structure of coriarin was finally confirmed by the base-catalized chemical conversion of tutin into coriarin, in which the lactone ring linkage was transposed from C-3 to C-2. Chemical investigation of sarcocarps was also undertaken in parallel, but neither sesquiterpene lactones nor related constituents were obtained. The results indicate that sesquiterpene lactones occur only in achenes of C. japonica berry, as is the case in other Coriaria species.
从日本马桑（马桑科）的瘦果（种子）中分离出一种名为马桑亭的新倍半萜内酯，同时还分离出已知成分马桑毒素、二氢马桑毒素和马桑苷，并通过光谱分析推断出其结构。马桑亭的结构最终通过碱催化将马桑毒素化学转化为马桑亭得以证实，其中内酯环的连接从C-3转移到了C-2。同时还对果肉进行了化学研究，但未获得倍半萜内酯或相关成分。结果表明，倍半萜内酯仅存在于日本马桑浆果的瘦果中，其他马桑属物种也是如此。
