雌激素受体和代谢型谷氨酸受体的相互作用及其对女性药物成瘾的影响。
Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females.
机构信息
Department of Neuroscience and Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
出版信息
Horm Behav. 2018 Aug;104:130-137. doi: 10.1016/j.yhbeh.2018.03.001. Epub 2018 Mar 10.
Abstract
Contribution to Special Issue on Fast effects of steroids. Estrogen receptors α and β (ERα and ERβ) have a unique relationship with metabotropic glutamate receptors (mGluRs) in the female rodent brain such that estradiol is able to recruit intracellular G-protein signaling cascades to influence neuronal physiology, structure, and ultimately behavior. While this association between ERs and mGluRs exists in many cell types and brain regions, its effects are perhaps most striking in the nucleus accumbens (NAc). This review will discuss the original characterization of ER/mGluR signaling and how estradiol activity in the NAc confers increased sensitivity to drugs of abuse in females through this mechanism.
摘要
为特刊“类固醇的快速作用”贡献力量。雌激素受体α和β（ERα 和 ERβ）与雌性啮齿动物大脑中的代谢型谷氨酸受体（mGluRs）有着独特的关系，使得雌二醇能够招募细胞内 G 蛋白信号级联反应来影响神经元的生理、结构，并最终影响行为。虽然这种 ER 和 mGluR 之间的关联存在于许多细胞类型和脑区，但它的作用在伏隔核（NAc）中最为显著。这篇综述将讨论 ER/mGluR 信号的最初特征，以及 NAc 中的雌二醇活性如何通过这种机制使女性对滥用药物的敏感性增加。
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