Department of Chemistry, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.
Department of Chemistry, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.
Int J Biol Macromol. 2018 Jul 1;113:1116-1124. doi: 10.1016/j.ijbiomac.2018.02.143. Epub 2018 Mar 29.
The purpose of this study is to fabricate 5-Fluorouracil sustained release matrix based on a novel, nontoxic, eco-friendly modified biopolymer. The sesbania gum based hydrogel has been prepared by microwave assisted method using acrylamide as a monomer and N,N Methylenebisacrylamide as a crosslinker. The crosslink copolymerization has been confirmed by several modern techniques such as FTIR, SEM, XRD, TGA, DSC, elemental analysis etc. The bioactive 5-Fluorouracil has been encapsulated via solvent swelling method and its release rate has been investigated in various pH dissolution medium through USP standard protocol. The synthesized hydrogel with higher degree of crosslinking exhibited slower release rate than that of hydrogel having lower degree of crosslinking. Thus, resulting higher t value, the release rate increases with increase in pH of the medium. Release kinetics suggests the non-Fickian release behaviour of the hydrogel.
本研究的目的是制备基于新型无毒、环保改性生物聚合物的 5-氟尿嘧啶控释基质。利用丙烯酰胺作为单体和 N,N-亚甲基双丙烯酰胺作为交联剂，采用微波辅助法制备了田菁胶基水凝胶。通过傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、X 射线衍射（XRD）、热重分析（TGA）、差示扫描量热法（DSC）、元素分析等现代技术对交联共聚物进行了确认。通过溶剂溶胀法将生物活性 5-氟尿嘧啶包封，并通过 USP 标准方案在各种 pH 溶解介质中研究了其释放率。交联程度较高的合成水凝胶的释放速率比交联程度较低的水凝胶慢。因此，随着介质 pH 值的增加，t 值增加，释放速率增加。释放动力学表明水凝胶的释放行为是非菲克扩散。
