Guo Jingli, Tang WenYi, Ye Xiaofeng, Wu Haixiang, Xu Gezhi, Liu Wei, Zhang Yongjin
Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China.
BMC Ophthalmol. 2018 Mar 5;18(1):69. doi: 10.1186/s12886-018-0737-y.
To evaluate the structural changes associated with visual acuity (VA) in patients with idiopathic macular telangiectasia (MT) type 1 using multimodal imaging modalities.
A retrospective study of 14 patients with MT type 1 and of 10 eyes from 10 healthy individuals as age-matched controls was conducted. The medical records of patients who had undergone colour fundus photography, spectral domain optical coherence tomography (OCT), fluorescein angiography and OCT angiography were reviewed. Central macular thickness (CMT), the areas of macular oedema and ellipsoid zone (EZ) disruption, EZ length, disorganization of the retinal inner layers (DRIL) and external limiting membrane (ELM) disruption, as measured by spectral domain OCT; and vascular density and the foveal avascular zones (FAZ) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), as measured by OCT angiography, were assessed in MT type 1 eyes and correlated with VA.
The mean baseline best-corrected VA of MT type 1 eyes was 0.45 ± 0.28. The mean CMT was 385.19 ± 75.21 μm in MT type 1 eyes and 252.43 ± 15.77 μm in contralateral eyes (Z = - 4.113, p < 0.001). The mean vessel density of the DCP was lower in MT type 1 eyes (47.25 ± 4.69%) than in contralateral eyes (53.93 ± 2.94%) and normal eyes (59.37 ± 2.50%) (Z = - 3.492, - 4.099; p < 0.001, < 0.001). The baseline logMAR VA was correlated with CMT (r = 0.682, p = 0.007), SCP density (r = - 0.652, p = 0.012), DCP density (r = - 0.700, p = 0.005), total area of EZ disruption (r = 0.649, p = 0.012); and total lengths of EZ (r = 0.681, p = 0.007), ELM (r = 0.699, p = 0.005) and DRIL (r = 0.707, p = 0.005) disruption in the 1-mm-diameter foveal region in MT type 1 eyes.
Decreased DCP density and the presence of DRIL may be predictive biomarkers of VA in MT type 1. CMT, SCP density, total area of EZ disruption, and lengths of EZ and ELM disruption within the 1-mm-diameter central region were strongly associated with VA.
使用多模态成像方式评估1型特发性黄斑毛细血管扩张症（MT）患者与视力（VA）相关的结构变化。
对14例1型MT患者以及10名健康个体的10只眼睛作为年龄匹配对照进行回顾性研究。回顾了接受彩色眼底照相、光谱域光学相干断层扫描（OCT）、荧光素血管造影和OCT血管造影的患者的病历。通过光谱域OCT测量中心黄斑厚度（CMT）、黄斑水肿面积和椭圆体带（EZ）破坏、EZ长度、视网膜内层紊乱（DRIL）和外界膜（ELM）破坏；通过OCT血管造影测量1型MT眼睛的血管密度以及浅表毛细血管丛（SCP）和深部毛细血管丛（DCP）的黄斑无血管区（FAZ），并将其与VA进行相关性分析。
1型MT眼睛的平均基线最佳矫正视力为0.45±0.28。1型MT眼睛的平均CMT为385.19±75.21μm，对侧眼睛为252.43±15.77μm（Z = -4.113，p < 0.001）。1型MT眼睛的DCP平均血管密度（47.25±4.69%）低于对侧眼睛（53.93±2.94%）和正常眼睛（59.37±2.50%）（Z = -3.492，-4.099；p < 0.001，< 0.001）。基线logMAR视力与CMT（r = 0.682，p = 0.007）、SCP密度（r = -0.652，p = 0.012）、DCP密度（r = -0.700，p = 0.005）、EZ破坏总面积（r = 0.649，p = 0.012）；以及1型MT眼睛直径1mm的黄斑区EZ总长度（r = 0.68l，p = 0.007）、ELM（r = 0.699，p = 0.005）和DRIL（r = 0.707，p = 0.005）破坏相关。
DCP密度降低和DRIL的存在可能是1型MT患者VA的预测生物标志物。CMT、SCP密度、EZ破坏总面积以及直径1mm中心区域内的EZ和ELM破坏长度与VA密切相关。
