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萘普生预防髋关节手术后异位骨化的疗效：一项荟萃分析。

Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis.

作者信息

Ma Ran, Chen Guan-Hong, Zhao Liu-Jing, Zhai Xi-Cheng

机构信息

Department of Orthopedics, Shanxian Central Hospital, No.1 Wenhua Road, Shanxian, Shandong, 274300, China.

出版信息

J Orthop Surg Res. 2018 Mar 5;13(1):48. doi: 10.1186/s13018-018-0747-8.

DOI:10.1186/s13018-018-0747-8
PMID:29506541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5839069/
Abstract

BACKGROUND

This meta-analysis aimed to assess whether the specific nonsteroidal anti-inflammatory drug (NSAID) naproxen has a role in reducing the occurrence of heterotopic ossification after hip surgery.

METHODS

Potential studies were identified in the following electronic databases: PubMed, EMBASE, Web of Science, Cochrane Library, and Google. We included studies involving hip surgery patients in which the intervention group received naproxen and the control group received placebo. The occurrence of heterotopic ossification and complications were the final outcomes. Stata 13.0 was used for the meta-analysis.

RESULTS

Four randomized controlled trials (RCTs) involving 269 patients were ultimately included in this meta-analysis. The use of naproxen was associated with a significant reduction in the occurrence of heterotopic ossification at 1.5-, 3-, 6-, and 12-month follow-ups (P < 0.05). There was no significant difference in the occurrence of complications between treatment and control groups (P > 0.05).

CONCLUSION

Our analysis indicates that naproxen can decrease the occurrence of heterotopic ossification without increasing complications in hip surgery patients. Due to the limited number of studies included, more high-quality RCTs are needed to identify the optimal dose of naproxen.

摘要

背景

本荟萃分析旨在评估特定的非甾体抗炎药萘普生在降低髋关节手术后异位骨化发生率方面是否起作用。

方法

在以下电子数据库中检索潜在研究：PubMed、EMBASE、科学网、考克兰图书馆和谷歌。我们纳入了涉及髋关节手术患者的研究，其中干预组接受萘普生，对照组接受安慰剂。异位骨化的发生情况和并发症为最终结局。使用Stata 13.0进行荟萃分析。

结果

本荟萃分析最终纳入了4项涉及269例患者的随机对照试验（RCT）。在1.5个月、3个月、6个月和12个月的随访中，使用萘普生与异位骨化发生率显著降低相关（P < 0.05）。治疗组和对照组之间并发症的发生率无显著差异（P > 0.05）。

结论

我们的分析表明，萘普生可降低髋关节手术患者异位骨化的发生率，且不增加并发症。由于纳入的研究数量有限，需要更多高质量的RCT来确定萘普生的最佳剂量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/b1ab81457952/13018_2018_747_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/5b35f947f23b/13018_2018_747_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/209607ff3bb9/13018_2018_747_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/707cbb20be88/13018_2018_747_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/ebd396fad245/13018_2018_747_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/814295c9a533/13018_2018_747_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/cad9c55a3660/13018_2018_747_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/27a9f78f8386/13018_2018_747_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/b1ab81457952/13018_2018_747_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/5b35f947f23b/13018_2018_747_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/209607ff3bb9/13018_2018_747_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/707cbb20be88/13018_2018_747_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/ebd396fad245/13018_2018_747_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/814295c9a533/13018_2018_747_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/cad9c55a3660/13018_2018_747_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/27a9f78f8386/13018_2018_747_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cca/5839069/b1ab81457952/13018_2018_747_Fig8_HTML.jpg

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