Golden Jubilee National Hospital, Clydebank, United Kingdom.
J Arthroplasty. 2018 Jun;33(6):1861-1867. doi: 10.1016/j.arth.2018.01.037. Epub 2018 Jan 31.
Surgical site infection (SSI) is a debilitating complication of lower limb arthroplasty with significant morbidity and increased costs. Numerous risk factors are associated with SSI.
In an effort to identify novel risk factors for SSI, we undertook a retrospective cohort study of 1832 primary total hip arthroplasties and 2100 primary total knee arthroplasties performed in our high volume arthroplasty unit over a 2-year period.
Two risk factors were identified for SSI following total hip arthroplasty: body mass index ≥30 and peri-operative blood transfusion. Eight risk factors were identified for SSI following total knee arthroplasty: hypertension, peri-operative blood transfusion, skin closure using 2-octyl cyanoacrylate, use of oral steroids, reduced serum mean cell volume, reduced mean cell hemoglobin, elevated serum neutrophil count, and use of warfarin or rivaroxaban for venous thromboembolism prophylaxis.
Our work proposes a number of previously undocumented risk factors in relation to SSI. Further investigation is required to ascertain the magnitude of their effect.
手术部位感染（SSI）是下肢关节置换术的一种严重并发症，具有显著的发病率和增加的成本。许多风险因素与 SSI 相关。
为了确定 SSI 的新的风险因素，我们对我们的高容量关节置换单位在 2 年内进行的 1832 例初次全髋关节置换术和 2100 例初次全膝关节置换术进行了回顾性队列研究。
全髋关节置换术后发现了两个 SSI 的风险因素：体重指数≥30 和围手术期输血。全膝关节置换术后发现了 8 个 SSI 的风险因素：高血压、围手术期输血、使用 2-辛基氰基丙烯酸酯进行皮肤闭合、使用口服类固醇、平均细胞体积减少、平均细胞血红蛋白减少、血清中性粒细胞计数升高，以及使用华法林或利伐沙班预防静脉血栓栓塞。
我们的工作提出了一些与 SSI 相关的以前未记录的风险因素。需要进一步调查以确定其影响的大小。
