文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

靶向递送达功能化上转换纳米颗粒用于脑胶质母细胞瘤的外部触发光热/光动力治疗。

Targeted Delivery of Functionalized Upconversion Nanoparticles for Externally Triggered Photothermal/Photodynamic Therapies of Brain Glioblastoma.

机构信息

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan.

Department of Chemical Engineering, National Chung Hsing University, Taichung 40249, Taiwan.

出版信息

Theranostics. 2018 Feb 4;8(5):1435-1448. doi: 10.7150/thno.22482. eCollection 2018.

DOI:10.7150/thno.22482
PMID:29507632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5835948/
Abstract

Therapeutic efficacy of glioblastoma multiforme (GBM) is often severely limited by poor penetration of therapeutics through blood-brain barrier (BBB) into brain tissues and lack of tumor targeting. In this regard, a functionalized upconversion nanoparticle (UCNP)-based delivery system which can target brain tumor and convert deep tissue-penetrating near-infrared (NIR) light into visible light for precise phototherapies on brain tumor was developed in this work. : The UCNP-based phototherapy delivery system was acquired by assembly of oleic acid-coated UCNPs with angiopep-2/cholesterol-conjugated poly(ethylene glycol) and the hydrophobic photosensitizers. The hybrid nanoparticles (ANG-IMNPs) were characterized by DLS, TEM, UV/vis and fluorescence spectrophotometer. Cellular uptake was examined by laser scanning confocal microscopy and flow cytometry. The PDT/PTT effect of ANG-IMNPs was evaluated using MTT assay. Tumor accumulation of NPs was determined by a non-invasive imaging system (IVIS). The anti-glioma effect of ANG-IMNPs was evaluated by immunohistochemical (IHC) examination of tumor tissues and Kaplan-Meier survival analysis. : data demonstrated enhanced uptake of ANG-IMNPs by murine astrocytoma cells (ALTS1C1) and pronounced cytotoxicity by combined NIR-triggered PDT and PTT. In consistence with the increased penetration of ANG-IMNPs through endothelial monolayer , the NPs have also shown significantly enhanced accumulation at brain tumor by IVIS. The IHC tissue examination confirmed prominent apoptotic and necrotic effects on tumor cells in mice receiving targeted dual photo-based therapies, which also led to enhanced median survival (24 days) as compared to the NP treatment without angiopep-2 (14 days). : and data strongly indicate that the ANG-IMNPs were capable of selectively delivering dual photosensitizers to brain astrocytoma tumors for effective PDT/PTT in conjugation with a substantially improved median survival. The therapeutic efficacy of ANG-IMNPs demonstrated in this study suggests their potential in overcoming BBB and establishing an effective treatment against GBM.

摘要

多形性胶质母细胞瘤 (GBM) 的治疗效果常常受到治疗药物通过血脑屏障 (BBB) 进入脑组织的能力差和缺乏肿瘤靶向性的严重限制。在这方面，本工作开发了一种基于功能化上转换纳米粒子 (UCNP) 的递药系统，该系统可以靶向脑肿瘤，并将穿透深层组织的近红外 (NIR) 光转化为可见光，从而对脑肿瘤进行精确的光疗。

UCNP 基光疗递药系统是通过将油酸包覆的 UCNP 与血管生成肽-2/胆固醇缀合的聚乙二醇和疏水性光敏剂组装而成的。混合纳米粒子 (ANG-IMNPs) 通过 DLS、TEM、UV/vis 和荧光分光光度计进行了表征。通过激光扫描共聚焦显微镜和流式细胞术检查细胞摄取情况。通过 MTT 测定评估了 ANG-IMNPs 的 PDT/PTT 效应。通过非侵入性成像系统 (IVIS) 测定 NPs 的肿瘤积累情况。通过肿瘤组织免疫组织化学 (IHC) 检查和 Kaplan-Meier 生存分析评估 ANG-IMNPs 的抗神经胶质瘤作用。

结果表明，ANG-IMNPs 被小鼠星形细胞瘤细胞 (ALTS1C1) 增强摄取，并通过 NIR 触发的 PDT 和 PTT 联合产生明显的细胞毒性。与 ANG-IMNPs 通过内皮单层的穿透增强一致，IVIS 也显示 NPs 在脑肿瘤处的积累明显增强。IHC 组织检查证实，接受靶向双重光基治疗的小鼠肿瘤细胞有明显的凋亡和坏死作用，与没有血管生成肽-2 的 NP 治疗相比，中位生存期也延长（24 天）（14 天）。

这些结果和讨论数据强烈表明，ANG-IMNPs 能够选择性地将双重光敏剂递送到脑星形细胞瘤肿瘤中，用于与实质性改善的中位生存期相结合的有效 PDT/PTT。本研究中展示的 ANG-IMNPs 的治疗效果表明了它们在克服 BBB 和建立针对 GBM 的有效治疗方法方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/78308ca790f9/thnov08p1435g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/10a7c39968b8/thnov08p1435g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/34411eb204ca/thnov08p1435g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/798232ce1d0b/thnov08p1435g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/07d72b06209a/thnov08p1435g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/16fe545f51f1/thnov08p1435g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/21dbf34d7807/thnov08p1435g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/78308ca790f9/thnov08p1435g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/10a7c39968b8/thnov08p1435g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/34411eb204ca/thnov08p1435g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/798232ce1d0b/thnov08p1435g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/07d72b06209a/thnov08p1435g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/16fe545f51f1/thnov08p1435g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/21dbf34d7807/thnov08p1435g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/5835948/78308ca790f9/thnov08p1435g007.jpg

相似文献

[1]
Targeted Delivery of Functionalized Upconversion Nanoparticles for Externally Triggered Photothermal/Photodynamic Therapies of Brain Glioblastoma.

Theranostics. 2018-2-4

[2]
Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles.

Biomaterials. 2012-8-11

[3]
Deep-penetrating photodynamic therapy with KillerRed mediated by upconversion nanoparticles.

Acta Biomater. 2017-3-15

[4]
Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma.

Biomaterials. 2011-3-21

[5]
An engineered cascade-sensitized red-emitting upconversion nanoplatform with a tandem hydrophobic hydration-shell and metal-phenolic network decoration for single 808 nm triggered simultaneous tumor PDT and PTT enhanced CDT.

Nanoscale. 2023-6-15

[6]
A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy.

Adv Mater. 2020-7

[7]
808 nm Light-triggered and hyaluronic acid-targeted dual-photosensitizers nanoplatform by fully utilizing Nd(3+)-sensitized upconversion emission with enhanced anti-tumor efficacy.

Biomaterials. 2016-5-21

[8]
Near Infrared-Activatable Biomimetic Nanoplatform for Tumor-Specific Drug Release, Penetration and Chemo-Photothermal Synergistic Therapy of Orthotopic Glioblastoma.

Int J Nanomedicine. 2024

[9]
Dual-selective photodynamic therapy with a mitochondria-targeted photosensitizer and fiber optic cannula for malignant brain tumors.

Biomater Sci. 2019-5-8

[10]
[Establishment of an Engineered Bacterial Membrane Biomimetic Nanodrug Delivery System and Its Role in the Treatment of Glioma].

Sichuan Da Xue Xue Bao Yi Xue Ban. 2024-7-20

引用本文的文献

[1]
A Systematic Review of Toxicity, Biodistribution, and Biosafety in Upconversion Nanomaterials: Critical Insights into Toxicity Mitigation Strategies and Future Directions for Safe Applications.

BME Front. 2025-5-23

[2]
Engineering Tumor-Specific Nanotheranostic Agent with MR Image-Guided NIR-II & -III Photodynamic Therapy to Combat Against Deeply Seated Orthotopic Glioblastoma.

Small Sci. 2024-7-14

[3]
State-of-the-art photodynamic therapy for malignant gliomas: innovations in photosensitizers and combined therapeutic approaches.

Explor Target Antitumor Ther. 2025-3-28

[4]
Emerging nanoplatforms towards microenvironment-responsive glioma therapy.

Med Oncol. 2025-1-15

[5]
Advancements and challenges in brain cancer therapeutics.

Exploration (Beijing). 2024-5-16

[6]
Temoporfin-Conjugated PEGylated Poly(,-dimethylacrylamide)-Coated Upconversion Colloid for NIR-Induced Photodynamic Therapy of Pancreatic Cancer.

Biomacromolecules. 2024-9-9

[7]
Nanomaterial-Based Strategies for Attenuating T-Cell-Mediated Immunodepression in Stroke Patients: Advancing Research Perspectives.

Int J Nanomedicine. 2024

[8]
Galectin inhibitors and nanoparticles as a novel therapeutic strategy for glioblastoma multiforme.

Am J Cancer Res. 2024-2-15

[9]
Zebrafish Insights into Nanomaterial Toxicity: A Focused Exploration on Metallic, Metal Oxide, Semiconductor, and Mixed-Metal Nanoparticles.

Int J Mol Sci. 2024-2-5

[10]
Molecularly Targeted Lanthanide Nanoparticles for Cancer Theranostic Applications.

Nanomaterials (Basel). 2024-1-31

本文引用的文献

[1]
Silica Cross-Linked Micellar Core--Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo.

J Biomed Nanotechnol. 2017-2

[2]
Molecular and Microenvironmental Determinants of Glioma Stem-Like Cell Survival and Invasion.

Front Oncol. 2017-6-16

[3]
Non-invasive approaches for drug delivery to the brain based on the receptor mediated transport.

Mater Sci Eng C Mater Biol Appl. 2017-7-1

[4]
Angiopep-2-conjugated poly(ethylene glycol)-- poly(ε-caprolactone) polymersomes for dual-targeting drug delivery to glioma in rats.

Int J Nanomedicine. 2017-3-16

[5]
Photothermal therapy of glioblastoma multiforme using multiwalled carbon nanotubes optimized for diffusion in extracellular space.

ACS Biomater Sci Eng. 2016-6-13

[6]
Efficacy of NGR peptide-modified PEGylated quantum dots for crossing the blood-brain barrier and targeted fluorescence imaging of glioma and tumor vasculature.

Nanomedicine. 2016-9-25

[7]
Through-skull fluorescence imaging of the brain in a new near-infrared window.

Nat Photonics. 2014-9

[8]
Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer.

Proc Natl Acad Sci U S A. 2016-7-12

[9]
Cell Mediated Photothermal Therapy of Brain Tumors.

J Neuroimmune Pharmacol. 2017-3

[10]
Self-assembled IR780-loaded transferrin nanoparticles as an imaging, targeting and PDT/PTT agent for cancer therapy.

Sci Rep. 2016-6-6

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索