Fang Fei, Zou Dan, Wang Wei, Yin Ying, Yin Tieying, Hao Shilei, Wang Bochu, Wang Guixue, Wang Yazhou
Key Laboratory of Bio-rheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Shapingba Street 174, Chongqing 404100, China.
Key Laboratory of Bio-rheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Shapingba Street 174, Chongqing 404100, China.
Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:1316-1327. doi: 10.1016/j.msec.2017.02.056. Epub 2017 Feb 24.
The blood brain barrier (BBB) is a physical and biochemical barrier that prevents entry of toxic compounds into brain for preserving homeostasis. However, the BBB also strictly limits influx of most therapeutic agents into the brain. One promising method for overcoming this problem to deliver drugs is receptor mediated transport (RMT) system, which employs the vesicular trafficking machinery to transport substrates across the BBB endothelium in a noninvasive manner. The conjugates of drug or drug-loaded vector linked with appropriate ligands specifically binds to the endogenous targeting receptor on the surface of the endothelial cells. Then drugs could enter the cell body by means of transcytosis and eventual releasing into the brain parenchyma. Over the past 20years, there have been significant developments of RMT targeting strategies. Here, we will review the recent advance of various promising RMT systems and discuss the capability of these approaches for drug delivery to the brain.
血脑屏障（BBB）是一种物理和生化屏障，可防止有毒化合物进入大脑以维持体内平衡。然而，血脑屏障也严格限制了大多数治疗药物进入大脑。一种有前景的克服这一问题以递送药物的方法是受体介导转运（RMT）系统，该系统利用囊泡运输机制以非侵入性方式将底物转运穿过血脑屏障内皮细胞。与适当配体连接的药物或载药载体缀合物特异性结合内皮细胞表面的内源性靶向受体。然后，药物可通过转胞吞作用进入细胞体，并最终释放到脑实质中。在过去20年中，RMT靶向策略有了重大进展。在此，我们将综述各种有前景的RMT系统的最新进展，并讨论这些方法用于向大脑递送药物的能力。
