Sasaki Teppei, Moriyama Katsuhiko, Togo Hideo
Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan.
Molecular Chirality Research Center, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan.
Beilstein J Org Chem. 2018 Feb 5;14:345-353. doi: 10.3762/bjoc.14.22. eCollection 2018.
Various 4-aryl-3-bromocoumarins were smoothly obtained in moderate yields in one pot by treating 3-aryl-2-propynoic acids with diaryliodonium triflates and KCO in the presence of CuCl, followed by the reaction with tetrabutylammonium bromide (TBAB) and NaSO. The obtained 3-bromo-4-phenylcoumarin was transformed into 4-phenylcoumarin derivatives bearing C-H, C-S, C-N, and C-C bonds at 3-position.
通过在氯化铜存在下，用双芳基三氟甲磺酸碘鎓盐和碳酸钾处理3-芳基-2-丙炔酸，然后与四丁基溴化铵（TBAB）和亚硫酸钠反应，一锅法以中等产率顺利得到了各种4-芳基-3-溴香豆素。所得到的3-溴-4-苯基香豆素被转化为在3-位带有C-H、C-S、C-N和C-C键的4-苯基香豆素衍生物。
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