Ren Guoxia, Liu Xu, Yu Zhendong, Li Jingjie, Niu Fanglin, Jin Tianbo, Liu Jikui, Chen Mingwei
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of School of Medicine of Xi'an Jiaotong University, Xi'an 710061, China.
Department of Intergrated Traditional Chinese and Western Medicine, Xi'an Chest Hospital, Xi'an 710100, China.
Oncotarget. 2018 Jan 3;9(10):9199-9205. doi: 10.18632/oncotarget.23905. eCollection 2018 Feb 6.
In this study, we investigated the association between the polymorphisms of telomerase reverse transcriptase () gene and the risk of chronic hepatitis B (CHB) in a Chinese Han population. Four single nucleotide polymorphisms (SNPs) in (rs10069690, rs2242652, rs2853677 and rs2853676) were genotyped from 224 CHB patients and 300 healthy controls using the Sequenom Mass-ARRAY platform. We used genetic model, haplotype analyses, chi-square test, logistic regression analysis to evaluate the association between SNPs and CHB risk. The relative risk was estimated by odd ratios (ORs) and 95% confidence intervals (CIs). We found that rs10069690 was significantly associated with an increased CHB risk in the dominant model (adjusted OR = 1.70, 95% CI: 1.06-2.71, = 0.031) and additive model (adjusted OR = 1.62, 95% CI: 1.09-2.41, = 0.018). The haplotype "TA" (rs10069690 and rs2242652) was found to be associated with an increased risk of CHB (adjusted OR = 1.58, 95% CI: 1.05-2.38, = 0.027). Our results suggested potential genetic contributes for in CHB development in a Chinese Han population. Future functional and association studies with larger sample sizes are required to confirm these findings.
在本研究中，我们调查了端粒酶逆转录酶（）基因多态性与中国汉族人群慢性乙型肝炎（CHB）风险之间的关联。使用Sequenom Mass-ARRAY平台对224例CHB患者和300例健康对照者进行了（rs10069690、rs2242652、rs2853677和rs2853676）4个单核苷酸多态性（SNP）的基因分型。我们采用遗传模型、单倍型分析、卡方检验、逻辑回归分析来评估SNP与CHB风险之间的关联。通过比值比（OR）和95%置信区间（CI）估计相对风险。我们发现，在显性模型（校正OR = 1.70，95%CI：1.06 - 2.71， = 0.031）和加性模型（校正OR = 1.62，95%CI：1.09 - 2.41， = 0.018）中，rs10069690与CHB风险增加显著相关。发现单倍型“TA”（rs10069690和rs2242652）与CHB风险增加相关（校正OR = 1.58，95%CI：1.05 - 2.38， = 0.027）。我们的结果提示在中国汉族人群中，在CHB发生发展过程中存在潜在的遗传贡献。未来需要进行更大样本量的功能和关联研究以证实这些发现。
