端粒酶逆转录酶（TERT）基因多态性与食管癌风险增加相关。
Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer.
作者信息
Wu Yifei, Yan Mengdan, Li Jing, Li Jingjie, Chen Zhengshuai, Chen Peng, Li Bin, Chen Fulin, Jin Tianbo, Chen Chao
机构信息
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.
Xi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi 710075, China.
出版信息
Oncotarget. 2017 Feb 7;8(6):10523-10530. doi: 10.18632/oncotarget.14451.
Single nucleotide polymorphisms (SNPs) in TERT may be associated with susceptibility to esophageal cancer. In this study, we analyzed the association between TERT SNPs and risk of esophageal cancer in 386 esophageal cancer patients and 495 healthy subjects from the Xi'an area of China. Of the four SNPs examined, rs10069690 and rs2242652 were correlated with esophageal cancer risk. Additionally, after adjusting for age and gender, the "Trs10069690Ars2242652", "Trs10069690Grs2242652" haplotypes were associated with an increased risk of esophageal cancer, while the and "Crs10069690Grs2242652" haplotype was associated with a decreased risk of esophageal cancer. These findings suggest that TERT polymorphisms may contribute to the development of esophageal cancer.
端粒酶逆转录酶（TERT）中的单核苷酸多态性（SNP）可能与食管癌易感性相关。在本研究中，我们分析了中国西安地区386例食管癌患者和495例健康受试者中TERT SNP与食管癌风险之间的关联。在所检测的4个SNP中，rs10069690和rs2242652与食管癌风险相关。此外，在调整年龄和性别后，“Trs10069690Ars2242652”、“Trs10069690Grs2242652”单倍型与食管癌风险增加相关，而“Crs10069690Grs2242652”单倍型与食管癌风险降低相关。这些发现表明TERT基因多态性可能促进食管癌的发生发展。
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