Department of Endocrinology and Metabolism, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, National Clinical Research Center for Metabolic Disease, The Second XiangYa Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, China.
Department of Spine Surgery, The Second XiangYa Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, China.
Arch Osteoporos. 2018 Mar 5;13(1):18. doi: 10.1007/s11657-018-0422-z.
The microstructure of autologous bone grafts from men over 50 years old and postmenopausal women undergoing spinal fusion were evaluated using micro-CT. We demonstrated postmenopausal women, especially those with osteoporosis (OP) presented more serious microarchitectural deterioration of bone grafts.
This study was undertaken to determine microstructural properties of cancellous bone used as autologous bone grafts from osteoporosis patients undergoing lumbar fusion by comparing microstructural indices to controls.
Cancellous bone specimens from spinous processes were obtained from 41 postmenopausal women (osteoporosis women, n = 19; controls, n = 22) and 26 men over 50 years old (osteoporosis men, n = 8; controls, n = 18) during lumbar fusion surgery. The microstructural parameters were measured using micro-CT.
Significant difference in bone volume fraction (BV/TV), specific bone surface (BS/BV), trabecular thickness (Tb.Th), and structure model index (SMI) value existed between postmenopausal women with OP and controls. Significant difference in trabecular number (Tb.N) existed between men over 50 years old with OP and controls. Postmenopausal women exhibited lower BV/TV, Tb.Th, and higher SMI value than men over 50 years old. Postmenopausal women with OP exhibited lower BV/TV, Tb.Th, and higher BS/BV than men over 50 years old with OP.
Post-menopausal women and older men with OP have worse bone quality in autografts than non-osteoporotic men and women. Postmenopausal women with OP presented serious microarchitectural deterioration in older population.
使用微 CT 评估了 50 岁以上男性和绝经后女性脊柱融合患者自体骨移植物的微观结构。我们发现绝经后女性，尤其是患有骨质疏松症（OP）的女性，骨移植物的微观结构恶化更为严重。
本研究旨在通过与对照组比较，确定骨质疏松症患者腰椎融合术中使用的自体松质骨的微观结构特性。
从 41 名绝经后女性（骨质疏松症女性，n = 19；对照组，n = 22）和 26 名 50 岁以上男性（骨质疏松症男性，n = 8；对照组，n = 18）的棘突中获得松质骨标本。使用微 CT 测量微观结构参数。
OP 绝经后女性与对照组之间的骨体积分数（BV/TV）、特定骨表面（BS/BV）、骨小梁厚度（Tb.Th）和结构模型指数（SMI）值存在显著差异。OP 老年男性与对照组之间的骨小梁数量（Tb.N）存在显著差异。OP 绝经后女性的 BV/TV、Tb.Th 和 SMI 值低于 50 岁以上男性，而 Tb.N 值高于 50 岁以上男性。OP 绝经后女性的 BV/TV、Tb.Th 和 BS/BV 低于 OP 老年男性。
OP 绝经后女性和老年男性的自体移植物骨质量比非骨质疏松症男性和女性差。OP 绝经后女性在老年人群中表现出严重的微观结构恶化。
