Psychiatric Laboratory and Mental Health Center, West China Hospital of Sichuan University, Chengdu, 610041, China.
Chinese Academy of Science Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.
Neurosci Bull. 2018 Jun;34(3):405-418. doi: 10.1007/s12264-018-0212-z. Epub 2018 Mar 5.
The striatum and globus pallidus are principal nuclei of the basal ganglia. Nissl- and acetylcholinesterase-stained sections of the tree shrew brain showed the neuroanatomical features of the caudate nucleus (Cd), internal capsule (ic), putamen (Pu), accumbens, internal globus pallidus, and external globus pallidus. The ic separated the dorsal striatum into the Cd and Pu in the tree shrew, but not in rats and mice. In addition, computer-based 3D images allowed a better understanding of the position and orientation of these structures. These data provided a large-scale atlas of the striatum and globus pallidus in the coronal, sagittal, and horizontal planes, the first detailed distribution of parvalbumin-immunoreactive cells in the tree shrew, and the differences in morphological characteristics and density of parvalbumin-immunoreactive neurons between tree shrew and rat. Our findings support the tree shrew as a potential model for human striatal disorders.
纹状体和苍白球是基底神经节的主要核团。树鼩脑的尼氏和乙酰胆碱酯酶染色切片显示了尾状核（Cd）、内囊（ic）、壳核（Pu）、伏隔核、内苍白球和外苍白球的神经解剖学特征。在树鼩中，ic 将背侧纹状体分隔为 Cd 和 Pu，但在大鼠和小鼠中并非如此。此外，基于计算机的 3D 图像可以更好地理解这些结构的位置和方向。这些数据提供了冠状面、矢状面和水平面的纹状体和苍白球的大型图谱，这是树鼩中副甲状腺球蛋白免疫反应细胞的首次详细分布，以及树鼩和大鼠之间副甲状腺球蛋白免疫反应神经元的形态特征和密度的差异。我们的发现支持树鼩作为人类纹状体疾病的潜在模型。
