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树鼩纹状体中尾状核、壳核和伏隔核的全脑传入输入

Whole-Brain Afferent Inputs to the Caudate Nucleus, Putamen, and Accumbens Nucleus in the Tree Shrew Striatum.

作者信息

Ni Rong-Jun, Shu Yu-Mian, Li Tao, Zhou Jiang-Ning

机构信息

Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu, China.

Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu, China.

出版信息

Front Neuroanat. 2021 Nov 2;15:763298. doi: 10.3389/fnana.2021.763298. eCollection 2021.

Abstract

Day-active tree shrews have a well-developed internal capsule (ic) that clearly separates the caudate nucleus (Cd) and putamen (Pu). The striatum consists of the Cd, ic, Pu, and accumbens nucleus (Acb). Here, we characterized the cytoarchitecture of the striatum and the whole-brain inputs to the Cd, Pu, and Acb in tree shrews by using immunohistochemistry and the retrograde tracer Fluoro-Gold (FG). Our data show the distribution patterns of parvalbumin (PV), nitric oxide synthase (NOS), calretinin (CR), and tyrosine hydroxylase (TH) immunoreactivity in the striatum of tree shrews, which were different from those observed in rats. The Cd and Pu mainly received inputs from the thalamus, motor cortex, somatosensory cortex, subthalamic nucleus, substantia nigra, and other cortical and subcortical regions, whereas the Acb primarily received inputs from the anterior olfactory nucleus, claustrum, infralimbic cortex, thalamus, raphe nucleus, parabrachial nucleus, ventral tegmental area, and so on. The Cd, Pu, and Acb received inputs from different neuronal populations in the ipsilateral (60, 67, and 63 brain regions, respectively) and contralateral (23, 20, and 36 brain regions, respectively) brain hemispheres. Overall, we demonstrate that there are species differences between tree shrews and rats in the density of PV, NOS, CR, and TH immunoreactivity in the striatum. Additionally, we mapped for the first time the distribution of whole-brain input neurons projecting to the striatum of tree shrews with FG injected into the Cd, Pu, and Acb. The similarities and differences in their brain-wide input patterns may provide new insights into the diverse functions of the striatal subregions.

摘要

日行性树鼩具有发育良好的内囊(ic),它清晰地分隔尾状核(Cd)和壳核(Pu)。纹状体由尾状核、内囊、壳核和伏隔核(Acb)组成。在这里,我们通过免疫组织化学和逆行示踪剂荧光金(FG)对树鼩纹状体的细胞结构以及尾状核、壳核和伏隔核的全脑输入进行了特征描述。我们的数据显示了树鼩纹状体中小清蛋白(PV)、一氧化氮合酶(NOS)、钙视网膜蛋白(CR)和酪氨酸羟化酶(TH)免疫反应性的分布模式,这些模式与在大鼠中观察到的不同。尾状核和壳核主要接收来自丘脑、运动皮层、体感皮层、底丘脑核、黑质以及其他皮层和皮层下区域的输入,而伏隔核主要接收来自前嗅核、屏状核、边缘下皮层、丘脑、中缝核、臂旁核、腹侧被盖区等的输入。尾状核、壳核和伏隔核分别从同侧(分别为60、67和63个脑区)和对侧(分别为23、20和36个脑区)脑半球的不同神经元群体接收输入。总体而言,我们证明树鼩和大鼠在纹状体中PV、NOS、CR和TH免疫反应性的密度上存在物种差异。此外,我们首次用FG注入树鼩的尾状核、壳核和伏隔核,绘制了投射到树鼩纹状体的全脑输入神经元的分布图。它们全脑输入模式的异同可能为纹状体亚区域的多种功能提供新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a74/8593333/199f38d862f9/fnana-15-763298-g001.jpg

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