Brédart Anne, Kop Jean-Luc, Antoniou Antonis C, Cunningham Alex P, De Pauw Antoine, Tischkowitz Marc, Ehrencrona Hans, Schmidt Marjanka K, Dolbeault Sylvie, Rhiem Kerstin, Easton Douglas F, Devilee Peter, Stoppa-Lyonnet Dominique, Schmutlzer Rita
Institut Curie, Supportive Care Department, Psycho-Oncology Unit, 26 rue d'Ulm, 75005 Cedex 05, Paris, France.
University Paris Descartes, 71 avenue Edouard Vaillant, 92774, Boulogne-Billancourt, France.
J Community Genet. 2019 Jan;10(1):61-71. doi: 10.1007/s12687-018-0362-8. Epub 2018 Mar 5.
The BOADICEA breast cancer (BC) risk assessment model and its associated Web Application v3 (BWA) tool are being extended to incorporate additional genetic and non-genetic BC risk factors. From an online survey through the BOADICEA website and UK, Dutch, French and Swedish national genetic societies, we explored the relationships between the usage frequencies of the BWA and six other common BC risk assessment tools and respondents' perceived importance of BC risk factors. Respondents (N = 443) varied in age, country and clinical seniority but comprised mainly genetics health professionals (82%) and BWA users (93%). Oncology professionals perceived reproductive, hormonal (exogenous) and lifestyle BC risk factors as more important in BC risk assessment compared to genetics professionals (p values < 0.05 to 0.0001). BWA was used more frequently by respondents who gave high weight to breast tumour pathology and low weight to personal BC history as BC risk factors. BWA use was positively related to the weight given to hormonal BC risk factors. The importance attributed to lifestyle and BMI BC risk factors was not associated with the use of BWA or any of the other tools. Next version of the BWA encompassing additional BC risk factors will facilitate more comprehensive BC risk assessment in genetics and oncology practice.
博阿迪西亚乳腺癌（BC）风险评估模型及其相关的网络应用程序v3（BWA）工具正在扩展，以纳入更多的遗传和非遗传BC风险因素。通过博阿迪西亚网站以及英国、荷兰、法国和瑞典的国家遗传学会进行的在线调查，我们探讨了BWA与其他六种常见BC风险评估工具的使用频率之间的关系，以及受访者对BC风险因素的感知重要性。受访者（N = 443）在年龄、国家和临床资历方面各不相同，但主要由遗传学健康专业人员（82%）和BWA用户（93%）组成。与遗传学专业人员相比，肿瘤学专业人员认为生殖、激素（外源性）和生活方式BC风险因素在BC风险评估中更为重要（p值<0.05至0.0001）。那些将乳腺肿瘤病理学视为高权重BC风险因素、将个人BC病史视为低权重BC风险因素的受访者更频繁地使用BWA。BWA的使用与赋予激素BC风险因素的权重呈正相关。赋予生活方式和BMI BC风险因素的重要性与BWA或任何其他工具的使用无关。包含更多BC风险因素的BWA下一版本将有助于在遗传学和肿瘤学实践中进行更全面的BC风险评估。
