使用减少扫描时间的动态对比增强磁共振成像测量血脑屏障通透性。
Measurement of blood-brain barrier permeability using dynamic contrast-enhanced magnetic resonance imaging with reduced scan time.
机构信息
Sackler Institute of Graduate Biomedical Science, New York University School of Medicine, New York, New York.
Bernard and Irene Schwartz Center for Biomedical Imaging, Radiology, New York University School of Medicine, New York, New York.
出版信息
Magn Reson Med. 2018 Oct;80(4):1686-1696. doi: 10.1002/mrm.27145. Epub 2018 Mar 5.
PURPOSE
To investigate the feasibility of measuring the subtle disruption of blood-brain barrier (BBB) using DCE-MRI with a scan duration shorter than 10 min.
METHODS
The extended Patlak-model (EPM) was introduced to include the effect of plasma flow (F ) in the estimation of vascular permeability-surface area product (PS). Numerical simulation studies were carried out to investigate how the reduction in scan time affects the accuracy in estimating contrast kinetic parameters. DCE-MRI studies of the rat brain were conducted with Fisher rats to confirm the results from the simulation. Intracranial F98 glioblastoma models were used to assess areas with different levels of permeability. In the normal brain tissues, the Patlak model (PM) and EPM were compared, whereas the 2-compartment-exchange-model (TCM) and EPM were assessed in the peri-tumor and the tumor regions.
RESULTS
The simulation study results demonstrated that scan time reduction could lead to larger bias in PS estimated by PM (>2000%) than by EPM (<47%), especially when F is low. When F was high as in the gray matter, the bias in PM-PS (>900%) were larger than that in EPM-PS (<42%). The animal study also showed similar results, where the PM parameters were more sensitive to the scan duration than the EPM parameters. It was also demonstrated that, in the peri-tumor region, the EPM parameters showed less change by scan duration than the TCM parameters.
CONCLUSION
The results of this study suggest that EPM can be used to measure PS with a scan duration of 10 min or less.
目的
研究使用扫描时间短于 10 分钟的 DCE-MRI 测量血脑屏障（BBB）细微破坏的可行性。
方法
引入扩展 Patlak 模型（EPM）以包括血浆流量（F）对血管通透性表面积乘积（PS）估计的影响。进行数值模拟研究以研究扫描时间减少如何影响估计对比动力学参数的准确性。使用 Fisher 大鼠进行 DCE-MRI 大鼠脑研究以确认模拟结果。使用颅内 F98 胶质母细胞瘤模型评估具有不同通透性水平的区域。在正常脑组织中，比较 Patlak 模型（PM）和 EPM，而在肿瘤周围和肿瘤区域评估 2 隔室交换模型（TCM）和 EPM。
结果
模拟研究结果表明，扫描时间减少可能导致 PM 估计的 PS 偏差更大（>2000%），而 EPM 则小于（<47%），特别是当 F 较低时。当 F 像灰质一样高时，PM-PS 的偏差（>900%）大于 EPM-PS 的偏差（<42%）。动物研究也显示出类似的结果，其中 PM 参数对扫描持续时间比 EPM 参数更敏感。还表明，在肿瘤周围区域，EPM 参数的扫描持续时间变化小于 TCM 参数。
结论
这项研究的结果表明，EPM 可以用于测量扫描时间为 10 分钟或更短的 PS。
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