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金雀异黄素通过 Nrf2/Keap1 和 NF-κB 通路减轻脂多糖诱导的人呼吸道上皮细胞炎症反应和黏蛋白及细胞外基质的表达。

Casticin alleviates lipopolysaccharide-induced inflammatory responses and expression of mucus and extracellular matrix in human airway epithelial cells through Nrf2/Keap1 and NF-κB pathways.

机构信息

Department of Pediatrics, The First People's Hospital of Shangqiu, Shangqiu, 476000, Henan, China.

出版信息

Phytother Res. 2018 Jul;32(7):1346-1353. doi: 10.1002/ptr.6067. Epub 2018 Mar 6.

DOI:10.1002/ptr.6067
PMID:29508465
Abstract

Asthma is one of the most common chronic inflammatory diseases of childhood, characterized by airway inflammation, mucus hypersecretion, and accumulation of extracellular matrix proteins. Casticin is an active compound that possesses broad biological activities including anti-inflammatory effect. However, the effect of casticin on asthma remains unknown. The aim of the present study was to evaluate the effect and mechanism of casticin on inflammatory responses and expression of mucus and extracellular matrix in human airway epithelial cells. The results showed that lipopolysaccharide induced the mRNA and protein levels of IL-6, IL-8, MUC5AC, collagen type I, and fibronectin in 16-HBE cells, whereas casticin treatment significantly inhibited the induction of lipopolysaccharide. Casticin induced Nrf2/Keap1 and inhibited nuclear factor κB pathways in 16-HBE cells. Knockdown of Nrf2 attenuated the effect of casticin on production of IL-6 and IL-8, expression of MUC5AC, collagen type I, and fibronectin in 16-HBE cells. In conclusion, the results indicated that casticin might be a novel therapeutic strategy for the treatment of asthma.

摘要

哮喘是儿童最常见的慢性炎症性疾病之一，其特征为气道炎症、黏液过度分泌和细胞外基质蛋白积累。丁香脂素是一种具有广泛生物活性的活性化合物，包括抗炎作用。然而，丁香脂素对哮喘的作用尚不清楚。本研究旨在评估丁香脂素对人气道上皮细胞炎症反应和黏液及细胞外基质表达的影响及机制。结果表明，脂多糖诱导 16-HBE 细胞中 IL-6、IL-8、MUC5AC、I 型胶原和纤维连接蛋白的 mRNA 和蛋白水平，而丁香脂素处理显著抑制脂多糖的诱导。丁香脂素诱导 16-HBE 细胞中的 Nrf2/Keap1 并抑制核因子 κB 通路。Nrf2 敲低减弱了丁香脂素对 16-HBE 细胞中 IL-6 和 IL-8 产生、MUC5AC、I 型胶原和纤维连接蛋白表达的影响。总之，这些结果表明，丁香脂素可能是治疗哮喘的一种新的治疗策略。

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