Xing Chenyang, Chen Shiyou, Qiu Meng, Liang Xin, Liu Quan, Zou Qingshuang, Li Zhongjun, Xie Zhongjian, Wang Dou, Dong Biqin, Liu Liping, Fan Dianyuan, Zhang Han
Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.
Adv Healthc Mater. 2018 Apr;7(7):e1701510. doi: 10.1002/adhm.201701510. Epub 2018 Mar 6.
Black phosphorus (BP) has recently emerged as an intriguing photothermal agent in photothermal therapy (PTT) against cancer by virtue of its high photothermal efficiency, biocompatibility, and biodegradability. However, naked BP is intrinsically characterized by easy oxidation (or natural degradation) and sedimentation inside the tumor microenvironment, leading to a short-term therapeutic and inhomogeneous photothermal effect. Development of BP-based nanocomposites for PTT against cancer therefore remains challenging. The present work demonstrates that green and injectable composite hydrogels based on cellulose and BP nanosheets (BPNSs) are of great efficiency for PTT against cancer. The resultant cellulose/BPNS-based hydrogel possesses 3D networks with irregular micrometer-sized pores and thin, strong cellulose-formed walls and exhibits an excellent photothermal response, enhanced stability, and good flexibility. Importantly, this hydrogel nanoplatform is totally harmless and biocompatible both in vivo and in vitro. This work may facilitate the development of BP-polymer-based photothermal agents in the form of hydrogels for biomedical-related clinic applications.
黑磷（BP）最近凭借其高光热效率、生物相容性和可生物降解性，成为光热疗法（PTT）中一种用于对抗癌症的有趣光热剂。然而，裸黑磷的固有特性是在肿瘤微环境中易于氧化（或自然降解）和沉降，导致短期治疗效果以及光热效应不均匀。因此，开发用于癌症光热治疗的基于黑磷的纳米复合材料仍然具有挑战性。目前的研究表明，基于纤维素和黑磷纳米片（BPNSs）的绿色可注射复合水凝胶在癌症光热治疗方面具有很高的效率。所得的基于纤维素/BPNS的水凝胶具有三维网络结构，其孔隙为不规则的微米级尺寸，且纤维素形成的壁薄而坚固，表现出优异的光热响应、增强的稳定性和良好的柔韧性。重要的是，这种水凝胶纳米平台在体内和体外均完全无害且具有生物相容性。这项工作可能会促进以水凝胶形式的基于黑磷 - 聚合物的光热剂在生物医学相关临床应用中的开发。
