MOE Key Laboratory of Laser Life Science & SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou 510631, Guangdong, China.
Biomater Sci. 2017 Sep 26;5(10):2048-2055. doi: 10.1039/c7bm00414a.
Black phosphorus (BP), a new type of two-dimensional nanomaterial, has attracted crucial attention in recent years owing to its excellent properties and great potential in various chemical, physical, and biological fields. In this study, BP nanosheets loaded with Au nanoparticles (BP-Au NSs) are obtained by a one-step facile synthetic method. The Au nanostructures can not only enhance the photothermal efficiency of the nanocomposites, but also endow BP-Au NSs with the potential to act as effective surface-enhanced Raman scattering (SERS) substrates for Raman biodetection. Cancer photothermal therapy (PTT) has been carried out in vitro and in vivo using BP-Au NSs as nanoagents. Under irradiation by an 808 nm laser, BP-Au NSs are capable of producing sufficient hyperthermia to destroy cancer cells, and the transplanted tumors in most of the tumor-bearing mice disappeared; BP-Au NSs are more effective than bare BP nanosheets. The PTT effect can also be monitored by a Raman technique that benefits from the high SERS activity of the BP-Au NSs. The molecular fingerprint features of breast tumors before and after PTT treatment were clearly identified using SERS analysis. The theranostic applications of BP-Au NSs exhibit promising potential in biomedicine.
黑磷（BP）作为一种新型二维纳米材料，由于其优异的性能和在化学、物理、生物等各个领域的巨大应用潜力，近年来引起了人们的极大关注。在本研究中，采用一步简便的合成方法得到了负载金纳米颗粒的 BP 纳米片（BP-Au NSs）。这些金纳米结构不仅可以提高纳米复合材料的光热效率，还使 BP-Au NSs 具有作为表面增强拉曼散射（SERS）基底进行拉曼生物检测的潜力。体外和体内实验均使用 BP-Au NSs 作为纳米试剂进行癌症光热治疗（PTT）。在 808nm 激光照射下，BP-Au NSs 可以产生足够的高热来破坏癌细胞，大多数荷瘤小鼠的移植瘤消失；BP-Au NSs 比裸 BP 纳米片更有效。PTT 效应还可以通过 Raman 技术进行监测，这得益于 BP-Au NSs 的高 SERS 活性。SERS 分析清楚地识别了 PTT 治疗前后乳腺癌的分子指纹特征。BP-Au NSs 的治疗应用在生物医学中表现出了有前景的应用潜力。
