Larose P, Ong H, du Souich P
Biochem Biophys Res Commun. 1987 Feb 27;143(1):140-4. doi: 10.1016/0006-291x(87)90641-3.
The effect of cyclophosphamide (CTX) on the renal handling of water and sodium and on plasma concentrations of vasopressin (AVP) and of the atrial natriuretic factor (ANF) was studied in the rabbit. When compared to controls, animals receiving CTX (100 mg/kg IV) showed an increase in the diuresis and natriuresis. In addition, ANF plasma concentrations increased by 84% between 4 and 8 hours after CTX, while AVP plasma concentrations remained unchanged. It is concluded that in the rabbit CTX has a diuretic and a natriuretic effect that may, at least in part, be related to the increase in ANF plasma concentrations.
在兔子身上研究了环磷酰胺（CTX）对肾脏水和钠处理以及血管加压素（AVP）和心房利钠因子（ANF）血浆浓度的影响。与对照组相比，接受CTX（100mg/kg静脉注射）的动物利尿和利钠增加。此外，CTX注射后4至8小时，ANF血浆浓度增加了84%，而AVP血浆浓度保持不变。得出的结论是，在兔子身上，CTX具有利尿和利钠作用，这可能至少部分与ANF血浆浓度的增加有关。
