Wolf J P, Nguyen N U, Baulay A, Dumoulin G, Berthelay S
Laboratoire de Physiologie, Faculté de Médecine, Besançon, France.
Eur J Appl Physiol Occup Physiol. 1990;61(3-4):284-8. doi: 10.1007/BF00357614.
In seven healthy male volunteers we investigated changes in plasma atrial natriuretic factor [( ANF]), arginine vasopressin [( AVP]) and plasma volume (PV) during supine immersion. Twenty minutes head-out water immersion in a supine position in a thermo-neutral water bath attenuated the increase in PV induced by 20 min in a supine position in air, but increased the mean plasma [ANF] from 32.0 pg.ml-1, SEM 5.1 to 53.3 pg.ml-1, SEM 3.6 and decreased the mean plasma [AVP] from 1.4 pg.ml-1, SEM 0.1 to 0.9 pg.ml-1, SEM 0.04. Simultaneously, diuresis and natriuresis increased markedly. During a 20-min control period in the supine posture without immersion, PV, plasma [ANF] and [AVP] remained unaffected while diuresis and natriuresis did not increase to the same extent. These data suggest that an increase in the central blood volume induced by a weak external hydrostatic pressure during supine immersion triggered the changes in plasma [ANF] and [AVP] and that the increase was probably due to a shift of blood volume from peripheral to central vessels. The changes in plasma [ANF] contributed to the changes in natriuresis.
在七名健康男性志愿者中，我们研究了仰卧浸泡期间血浆心钠素[（ANF）]、精氨酸加压素[（AVP）]和血浆容量（PV）的变化。在热中性水浴中仰卧位进行20分钟头部露出水面的水浸，减弱了在空气中仰卧20分钟所诱导的PV增加，但使平均血浆[ANF]从32.0 pg.ml-1（标准误5.1）增加到53.3 pg.ml-1（标准误3.6），并使平均血浆[AVP]从1.4 pg.ml-1（标准误0.1）降低到0.9 pg.ml-1（标准误0.04）。同时，利尿和利钠显著增加。在无浸泡的仰卧姿势下的20分钟对照期内，PV、血浆[ANF]和[AVP]未受影响，而利尿和利钠未增加到相同程度。这些数据表明，仰卧浸泡期间由微弱的外部静水压力引起的中心血容量增加触发了血浆[ANF]和[AVP]的变化，并且这种增加可能是由于血容量从外周血管转移到中心血管所致。血浆[ANF]的变化促成了利钠的变化。
