1Department of Epidemiology,Johns Hopkins Bloomberg School of Public Health,615 N Wolfe Street, Baltimore, MD 21205,USA.
2Department of Nutrition,Harvard T.H. Chan School of Public Health,665 Huntington Avenue, Boston, MA 02115,USA.
Br J Nutr. 2018 Mar;119(5):570-580. doi: 10.1017/S0007114517003841.
Few studies have evaluated the relationships between intake of sugar-sweetened beverages (SSB) and intermediate biomarkers of cardiometabolic risk. Associations between artificially sweetened beverages (ASB) and fruit juice with cardiometabolic biomarkers are also unclear. We investigated habitual SSB, ASB and fruit juice intake in relation to biomarkers of hepatic function, lipid metabolism, inflammation and glucose metabolism. We analysed cross-sectional data from 8492 participants in the Nurses' Health Study who were free of diabetes and CVD. Multivariate linear regression was used to assess the associations of SSB, ASB and fruit juice intake with concentrations of fetuin-A, alanine transaminase, γ-glutamyl transferase, TAG, HDL-cholesterol, LDL-cholesterol, total cholesterol, C-reactive protein (CRP), intracellular adhesion molecule 1 (ICAM-1), vascular cell adhesion protein 1, adiponectin, insulin and HbA1c as well as total cholesterol:HDL-cholesterol ratio. More frequent intake of SSB was significantly associated with higher concentrations of fetuin-A, TAG, CRP, ICAM-1, adiponectin and insulin, a higher total cholesterol:HDL-cholesterol ratio, and a lower concentration of HDL-cholesterol (P trend ranges from <0·0001 to 0·04) after adjusting for demographic, medical, dietary and lifestyle variables. ASB intake was marginally associated with increased concentrations of CRP (P trend=0·04) and adiponectin (P trend=0·01). Fruit juice intake was associated with increased concentrations of TAG and HbA1c and a lower concentration of adiponectin (P trend ranges from <0·0001 to 0·01). In conclusion, habitual intake of SSB was associated with adverse levels of multiple cardiometabolic biomarkers. Associations between ASB and fruit juice with cardiometabolic risk markers warrant further exploration.
很少有研究评估摄入含糖饮料（SSB）与心血管代谢风险的中间生物标志物之间的关系。人工甜味饮料（ASB）和果汁与心血管代谢生物标志物之间的关系也不清楚。我们研究了习惯性 SSB、ASB 和果汁的摄入量与肝功能、脂质代谢、炎症和葡萄糖代谢的生物标志物之间的关系。我们分析了来自护士健康研究的 8492 名参与者的横断面数据，这些参与者无糖尿病和 CVD。多变量线性回归用于评估 SSB、ASB 和果汁摄入量与胎球蛋白 A、丙氨酸转氨酶、γ-谷氨酰转移酶、TAG、HDL-胆固醇、LDL-胆固醇、总胆固醇、C 反应蛋白 (CRP)、细胞间黏附分子 1 (ICAM-1)、血管细胞黏附蛋白 1、脂联素、胰岛素和 HbA1c 以及总胆固醇：HDL-胆固醇比值的关系。更频繁地摄入 SSB 与胎球蛋白 A、TAG、CRP、ICAM-1、脂联素和胰岛素浓度升高、总胆固醇：HDL-胆固醇比值升高和 HDL-胆固醇浓度降低（P 趋势范围从 <0·0001 到 0·04）相关，这些差异在调整了人口统计学、医学、饮食和生活方式变量后仍然存在。ASB 摄入量与 CRP（P 趋势=0·04）和脂联素（P 趋势=0·01）浓度升高相关。果汁摄入与 TAG 和 HbA1c 浓度升高和脂联素浓度降低相关（P 趋势范围从 <0·0001 到 0·01）。总之，习惯性摄入 SSB 与多种心血管代谢生物标志物的不良水平有关。ASB 和果汁与心血管代谢风险标志物之间的关系需要进一步探讨。
