Yu Zhi, Malik Vasanti S, Keum NaNa, Hu Frank B, Giovannucci Edward L, Stampfer Meir J, Willett Walter C, Fuchs Charles S, Bao Ying
Division of Rheumatology, Allergy and Immunology, Section of Clinical Sciences, Brigham and Women's Hospital, Boston, MA;
Departments of Nutrition and.
Am J Clin Nutr. 2016 Sep;104(3):722-8. doi: 10.3945/ajcn.116.134205. Epub 2016 Jul 27.
Increased nut consumption has been associated with reduced risk of cardiovascular disease and type 2 diabetes, as well as a healthy lipid profile. However, the associations between nut consumption and inflammatory biomarkers are unclear.
We investigated habitual nut consumption in relation to inflammatory biomarkers in 2 large cohorts of US men and women.
We analyzed cross-sectional data from 5013 participants in the Nurses' Health Study (NHS) and Health Professionals Follow-Up Study (HPFS) who were free of diabetes. Nut intake, defined as intake of peanuts and other nuts, was estimated from food-frequency questionnaires, and cumulative averages from 1986 and 1990 in the NHS and from 1990 and 1994 in the HPFS were used. Plasma biomarkers were collected in 1989-1990 in the NHS and 1993-1995 in the HPFS. Multivariate linear regression was used to assess the associations of nut consumption with fasting plasma C-reactive protein (CRP, n = 4941), interleukin 6 (IL-6, n = 2859), and tumor necrosis factor receptor 2 (TNFR2, n = 2905).
A greater intake of nuts was associated with lower amounts of a subset of inflammatory biomarkers, after adjusting for demographic, medical, dietary, and lifestyle variables. The relative concentrations (ratios) and 95% CIs comparing subjects with nut intake of ≥5 times/wk and those in the categories of never or almost never were as follows: CRP: 0.80 (0.69, 0.90), P-trend = 0.0003; and IL-6: 0.86 (0.77, 0.97), P-trend = 0.006. These associations remained significant after further adjustment for body mass index. No significant association was observed with TNFR2. Substituting 3 servings of nuts/wk for 3 servings of red meat, processed meat, eggs, or refined grains/wk was associated with significantly lower CRP (all P < 0.0001) and IL-6 (P ranges from 0.001 to 0.017).
Frequent nut consumption was associated with a healthy profile of inflammatory biomarkers.
增加坚果摄入量与降低心血管疾病和2型糖尿病风险以及健康的血脂状况有关。然而，坚果摄入量与炎症生物标志物之间的关联尚不清楚。
我们在2个美国男性和女性大型队列中研究了习惯性坚果摄入量与炎症生物标志物之间的关系。
我们分析了护士健康研究（NHS）和卫生专业人员随访研究（HPFS）中5013名无糖尿病参与者的横断面数据。通过食物频率问卷估计坚果摄入量，定义为花生和其他坚果的摄入量，并使用NHS中1986年和1990年以及HPFS中1990年和1994年的累积平均值。NHS在1989 - 1990年以及HPFS在1993 - 1995年收集血浆生物标志物。使用多变量线性回归评估坚果摄入量与空腹血浆C反应蛋白（CRP，n = 4941）、白细胞介素6（IL - 6，n = 2859）和肿瘤坏死因子受体2（TNFR2，n = 2905）之间的关联。
在调整人口统计学、医学、饮食和生活方式变量后，较高的坚果摄入量与一部分炎症生物标志物含量较低有关。比较每周坚果摄入量≥5次的受试者与从不或几乎从不摄入坚果类别的受试者的相对浓度（比率）及95%置信区间如下：CRP：0.80（0.69，0.90），P趋势 = 0.0003；IL - 6：0.86（0.77，0.97），P趋势 = 0.006。在进一步调整体重指数后，这些关联仍然显著。未观察到与TNFR2有显著关联。用每周3份坚果替代每周3份红肉、加工肉、蛋类或精制谷物与显著降低的CRP（所有P < 0.0001）和IL - 6（P范围为0.001至0.017）相关。
经常食用坚果与炎症生物标志物的健康状况有关。
