Department of Respiratory Medicine, Ningbo First Hospital, Ningbo, China; Ningbo University School of Medicine, Ningbo, China.
Department of Respiratory Medicine, Ningbo First Hospital, Ningbo, China.
Ann Allergy Asthma Immunol. 2018 Mar;120(3):310-317.e2. doi: 10.1016/j.anai.2017.12.011.
Previous studies have suggested that allergic disorders are associated with an increased risk of depression. However, the results are conflicting.
To determine the association between allergic disorders and depression based on large-scale studies.
We reviewed relevant articles obtained from PubMed and Embase. Studies were eligible if they reported an association between allergic disorders and depression and provided available data. Study selection, data extraction, and analyses were undertaken. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated.
Of 1,827 studies identified, 51 including more than 2.5 million participants met our inclusion criteria. Overall, the results showed that allergic disorders were associated with a significant increased risk of depression (pooled RR 1.59, 95% CI 1.48-1.71). A higher risk of depression also was observed in patients with asthma (RR 1.59, 95% CI 1.46-1.74) and those with allergic rhinitis (RR 1.57, 95% CI 1.27-1.93). Subgroup analyses were conducted based on sex and age. Children (RR 1.66, 95% CI 1.41-1.96) and adults (RR 1.58, 95% CI 1.44-1.74) with allergic disorders had a higher risk of depression than controls. However, no significant association was found between allergic disorders and risk of depression in male subjects (RR 1.37, 95% CI 0.98-1.91), but a positive association was detected in female subjects (RR 1.65, 95% CI 1.44-1.89).
The results from our study showed that allergic disorders significantly increased the risk of depression.
先前的研究表明，过敏疾病与抑郁风险增加有关。然而，结果存在争议。
基于大规模研究，确定过敏疾病与抑郁之间的关联。
我们检索了 PubMed 和 Embase 中的相关文章。如果研究报告了过敏疾病与抑郁之间的关联，并提供了可用数据，则认为其符合纳入标准。我们进行了研究选择、数据提取和分析。计算了合并的相对风险（RR）及其 95%置信区间（CI）。
在确定的 1827 篇研究中，有 51 篇研究纳入了超过 250 万名参与者，符合我们的纳入标准。总体而言，结果表明过敏疾病与抑郁风险显著增加相关（合并 RR 1.59，95% CI 1.48-1.71）。哮喘患者（RR 1.59，95% CI 1.46-1.74）和过敏性鼻炎患者（RR 1.57，95% CI 1.27-1.93）的抑郁风险也更高。还根据性别和年龄进行了亚组分析。患有过敏疾病的儿童（RR 1.66，95% CI 1.41-1.96）和成人（RR 1.58，95% CI 1.44-1.74）患抑郁的风险高于对照组。然而，在男性受试者中，过敏疾病与抑郁风险之间没有显著关联（RR 1.37，95% CI 0.98-1.91），但在女性受试者中存在阳性关联（RR 1.65，95% CI 1.44-1.89）。
本研究结果表明，过敏疾病显著增加了抑郁的风险。
