Wang Jing, Xiao Dongqiong, Chen Huayou, Hu Juan
Department of Radiology, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Department of Emergency, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), West China Second University Hospital, Sichuan University, Ministry of Education, Chengdu, 610041, China.
Allergy Asthma Clin Immunol. 2021 Oct 24;17(1):111. doi: 10.1186/s13223-021-00615-5.
Several primary studies evaluated the association between rhinitis and the incidence of depression and yielded inconsistent results. We conducted a meta-analysis of studies evaluating the association between rhinitis and depression.
We searched the EMBASE, PubMed and Cochrane Library databases for studies published in English before April 1, 2019. The studies were included if they reported any type of rhinitis in relation to depression. Two authors independently extracted the data. The odds ratios (ORs) were pooled using a random-effects model. Stratified analyses were conducted to evaluate the association.
Among the 3472 initially identified studies, we included 14 studies involving a total of 19.36 ± 1.1 million participants according to predefined inclusion criteria. The associations between rhinitis (R), allergic rhinitis (AR), and nonallergic rhinitis (NAR) and depression were significant with ORs of 1.86 (95% CI 1.32 to 2.62, p < 0.05), 1.54 (95% CI 1.24 to 1.90, p < 0.05), and 2.15 (95% CI 1.49 to 3.09, p < 0.05), respectively. The results were consistent and statistically significant in all subgroup analyses.
Rhinitis was associated with an increased risk of depression. Further prospective studies involving large sample sizes are required to confirm the results by considering more confounders and clarify the mechanisms.
多项初步研究评估了鼻炎与抑郁症发病率之间的关联，但结果不一致。我们对评估鼻炎与抑郁症关联的研究进行了荟萃分析。
我们检索了EMBASE、PubMed和Cochrane图书馆数据库，以查找2019年4月1日前发表的英文研究。如果研究报告了任何类型的鼻炎与抑郁症的关系，则将其纳入。两位作者独立提取数据。使用随机效应模型汇总比值比（OR）。进行分层分析以评估关联。
在最初识别的3472项研究中，根据预先定义的纳入标准，我们纳入了14项研究，共涉及1936±110万参与者。鼻炎（R）、过敏性鼻炎（AR）和非过敏性鼻炎（NAR）与抑郁症之间的关联具有统计学意义，OR分别为1.86（95%CI 1.32至2.62，p<0.05）、1.54（95%CI 1.24至1.90，p<0.05）和2.15（95%CI 1.49至3.09，p<0.05）。在所有亚组分析中，结果均一致且具有统计学意义。
鼻炎与抑郁症风险增加相关。需要进一步开展涉及大样本量的前瞻性研究，通过考虑更多混杂因素来证实结果并阐明其机制。
