Unidad de Investigación Médica en Inmunología e Infectología, Hospital de Infectología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, CDMX, México.
Departamento de Microbiología, Programa en Biomedicina y Biotecnología Molecular, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, CDMX, México.
J Med Virol. 2018 Jul;90(7):1277-1282. doi: 10.1002/jmv.25070. Epub 2018 Apr 23.
The HCV 5'UTR, Core/E1, and NS5B regions of samples from fifty patients infected with the hepatitis C virus (HCV) were analyzed. Seventeen patients were identified with genotype (GT) 1b, eleven with GT-1a, nine with GT-2b and four with GT-3a. Two rare subtypes were detected: GT-2j in two patients and GT-2r in one patient. Three patients had mixed infections: one with GT-2k + 2j and two with GT-1b + 2b. This work identifies HCV GTs, 2j, 2k, and 2r for the first time in Mexico.
对 50 名感染丙型肝炎病毒（HCV）的患者的样本的 HCV 5'UTR、核心/E1 和 NS5B 区进行了分析。鉴定出 17 名 1b 基因型（GT）患者，11 名 1a 基因型患者，9 名 2b 基因型患者和 4 名 3a 基因型患者。检测到两种罕见的亚型：两名患者为 2j 基因型，一名患者为 2r 基因型。三名患者存在混合感染：一名患者为 2k + 2j 混合感染，两名患者为 1b + 2b 混合感染。本研究首次在墨西哥发现 HCV GTs 2j、2k 和 2r。
