Vanderwolf C H
Behav Brain Res. 1987 Jan;23(1):43-57. doi: 10.1016/0166-4328(87)90241-5.
Previous work has indicated that activation of the cerebral cortex (i.e. elicitation of low-voltage fast activity in the neocortex and rhythmical slow activity in the hippocampus) is dependent on corticipetal cholinergic and serotonergic projections. Treatment with a combination of p-chlorophenylalanine (an inhibitor of the synthesis of serotonin) plus atropine or scopolamine (muscarinic cholinergic antagonists) can suppress all cerebral activation. In this paper, the behavioral effects of single or combined blockade of cholinergic and serotonergic neurotransmission were studied using a shock avoidance test, an open field test, a swim-to-platform test, a hypothalamic self-stimulation test and a test of grooming behavior. The results show that blockade of cerebral activation produces a condition analogous to global dementia but does not produce sleep or coma. The hypothesis that cholinergic and serotonergic neurotransmission provides a basis for learning and memory is discussed critically.
先前的研究表明，大脑皮层的激活（即新皮层中低电压快速活动和海马体中有节律的慢活动的诱发）依赖于向心性胆碱能和5-羟色胺能投射。用对氯苯丙氨酸（一种5-羟色胺合成抑制剂）加阿托品或东莨菪碱（毒蕈碱胆碱能拮抗剂）联合治疗可抑制所有大脑激活。在本文中，使用回避电击试验、旷场试验、游向平台试验、下丘脑自我刺激试验和梳理行为试验研究了胆碱能和5-羟色胺能神经传递单一或联合阻断的行为效应。结果表明，大脑激活的阻断产生了一种类似于全身性痴呆的状态，但不会导致睡眠或昏迷。对胆碱能和5-羟色胺能神经传递为学习和记忆提供基础这一假说进行了批判性讨论。
