Meador K J, Loring D W, Davis H C, Sethi K D, Patel B R, Adams R J, Hammond E J
Department of Neurology, Medical College of Georgia, Augusta 30912.
J Clin Exp Neuropsychol. 1989 Mar;11(2):252-60. doi: 10.1080/01688638908400887.
The effects of scopolamine (anticholinergic) and methysergide (antiserotonergic) on memory and long-latency auditory cognitive evoked potentials (EPs) were tested in 16 normal adults. Recent memory was impaired by both drugs. In contrast, scopolamine, but not methysergide, significantly delayed P3 latency and decreased P3 amplitude. Immediate memory and the earlier EP components (i.e., N1 and P2) were unaffected. The findings support the hypothesis that cholinergic neurons are important in the neuronal networks generating the P3 potential. Serotonergic neurons do not appear to play a major role in the networks that generate the P3.
在16名正常成年人中测试了东莨菪碱（抗胆碱能药物）和甲基麦角新碱（抗5-羟色胺药物）对记忆及长潜伏期听觉认知诱发电位（EPs）的影响。两种药物均损害近期记忆。相比之下，东莨菪碱显著延迟P3潜伏期并降低P3波幅，而甲基麦角新碱则无此作用。即刻记忆以及较早的诱发电位成分（即N1和P2）未受影响。这些发现支持了胆碱能神经元在产生P3电位的神经网络中起重要作用的假说。5-羟色胺能神经元似乎在产生P3的神经网络中不发挥主要作用。
