Hughes B R, Holt P J, Marks R
Br J Dermatol. 1987 Feb;116(2):241-2. doi: 10.1111/j.1365-2133.1987.tb05819.x.
We report two cases of fixed drug eruption due to trimethoprim. Fixed drug eruption is a distinct entity characterized by the development of circular erythematous skin lesions which over a period of time become violaceous and leave an area of hyperpigmentation. Mucous membranes also may be affected. With re-administration of the drug the lesions recur in the same area but may extend to further new areas with each challenge.
我们报告了两例因甲氧苄啶引起的固定性药疹。固定性药疹是一种独特的病症，其特征为出现圆形红斑性皮肤损害，这些损害在一段时间后会变成紫蓝色，并留下色素沉着区域。黏膜也可能受到影响。再次使用该药物时，损害会在同一部位复发，但每次发作时可能会扩展到更多新的部位。
