Gómez B, Sastre J, Azofra J, Sastre A
Allergol Immunopathol (Madr). 1985 Mar-Apr;13(2):87-91.
We presented 21 patients with fixed drug eruptions. All of them had positive provocation tests, showing the usefulness of this test for diagnosis. The lesions appeared on the skin or mucous membranes within 20 min. to 10 hours, after an oral provocation test with a sub-therapeutic dose. In those cases where we performed the basophil degranulation test, they were all negative. The drug more frequently implicated was cotrimoxazole (71%). In one patient the eruption was produced by oral neomycin.
我们报告了21例固定性药疹患者。他们所有人的激发试验结果均为阳性，表明该试验对诊断有用。在口服亚治疗剂量进行激发试验后，20分钟至10小时内，皮损出现在皮肤或黏膜上。在我们进行嗜碱性粒细胞脱粒试验的那些病例中，结果均为阴性。最常涉及的药物是复方新诺明（71%）。在1例患者中，皮疹由口服新霉素引起。
