Binet J L, Travade P, Chastang C, Dighiero G, Merle-Béral H, Raphael M
C R Seances Soc Biol Fil. 1986;180(5):503-11.
The present study is concerned with clinical prognostic classifications of chronic lymphocytic leukemia derived from numerous statistics and multivariate survival analysis. We analyse the prognostic significance of some biological patterns: bone marrow histological studies, lymph node biopsies, size, structure and doubling time of blood lymphocytes, tumoral markers and karyotype analysis. The problem of the monoclonal clone origin is discussed: differentiation abnormality or proliferation of a physiological clone.
本研究涉及源自大量统计数据和多变量生存分析的慢性淋巴细胞白血病的临床预后分类。我们分析了一些生物学模式的预后意义：骨髓组织学研究、淋巴结活检、血液淋巴细胞的大小、结构和倍增时间、肿瘤标志物以及核型分析。讨论了单克隆克隆起源的问题：生理克隆的分化异常或增殖。
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