School of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, China.
Southern Medical University, Guangzhou, Guangdong, China.
Eur J Immunol. 2018 Jun;48(6):915-922. doi: 10.1002/eji.201747157. Epub 2018 Apr 11.
An atypical guanine exchange factor, Dock2 is specifically expressed in hematopoietic cells and regulates activation and migration of immune cells through activating Ras-related C3 botulinum toxin substrate (Rac). Dock2 was shown to be critical in the development of various inflammatory diseases, including allergic diseases, HIV infection, and graft rejection in organ transplantation. DOCK2 mutation in infants was recently identified to be associated with T and B cell combined immunodeficiency. Furthermore, Dock2 is involved in host protection during enteric bacterial infection and is also associated with the proliferation of cancer cells. It was also shown that patients with digestive tract cancer had high frequency mutation of DOCK2. This review summarizes the latest research progresses on the role of Dock2 for the development of various inflammatory diseases and cancers, and discusses the potential application of Dock2 modulators for patient treatment.
一种非典型的鸟嘌呤交换因子，Dock2 特异性地在造血细胞中表达，并通过激活 Ras 相关 C3 肉毒杆菌毒素底物（Rac）来调节免疫细胞的激活和迁移。Dock2 被证明在各种炎症性疾病的发展中至关重要，包括过敏疾病、HIV 感染和器官移植中的移植物排斥。最近发现，婴儿中的 DOCK2 突变与 T 和 B 细胞联合免疫缺陷有关。此外，Dock2 参与肠道细菌感染期间的宿主保护，并且还与癌细胞的增殖有关。还表明，患有消化道癌症的患者的 DOCK2 高频突变。本综述总结了 Dock2 在各种炎症性疾病和癌症发展中的作用的最新研究进展，并讨论了 Dock2 调节剂在患者治疗中的潜在应用。
