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1
Lysis of autologous tumor cells by blood lymphocytes activated in autologous mixed lymphocyte tumor cell culture--no correlation with the postsurgical clinical course.自体混合淋巴细胞肿瘤细胞培养中激活的血液淋巴细胞对自体肿瘤细胞的溶解作用——与术后临床病程无关。
Cancer Immunol Immunother. 1987;24(2):180-3. doi: 10.1007/BF00205598.
2
Suppression of T-cell response in autologous mixed lymphocyte-tumor culture by large granular lymphocytes.大颗粒淋巴细胞对自体混合淋巴细胞-肿瘤培养中T细胞反应的抑制作用。
J Natl Cancer Inst. 1986 Mar;76(3):389-98.
3
Lysis of fresh human tumor cells by autologous large granular lymphocytes and T-lymphocytes: two distinct killing activities induced by coculture with autologous tumor.自体大颗粒淋巴细胞和T淋巴细胞对新鲜人肿瘤细胞的裂解作用：与自体肿瘤共培养诱导的两种不同杀伤活性。
J Natl Cancer Inst. 1984 Dec;73(6):1285-92.
4
Lysis of autologous tumor cells by blood lymphocytes tested at the time of surgery. Correlation with the postsurgical clinical course.手术时检测血液淋巴细胞对自体肿瘤细胞的溶解作用。与术后临床病程的相关性。
Cancer Immunol Immunother. 1986;21(1):69-76. doi: 10.1007/BF00199380.
5
Autologous mixed lymphocyte-tumor reaction and autologous mixed lymphocyte reaction. II. Generation of specific and non-specific killer T cells capable of lysing autologous tumor.自体混合淋巴细胞-肿瘤反应和自体混合淋巴细胞反应。II. 能够裂解自体肿瘤的特异性和非特异性杀伤性T细胞的产生。
Int J Cancer. 1988 May 15;41(5):651-6. doi: 10.1002/ijc.2910410502.
6
Tumor biopsy cells participating in systems in which cytotoxicity of lymphocytes is generated. Autologous and allogeneic studies.参与淋巴细胞细胞毒性产生系统的肿瘤活检细胞。自体和异体研究。
Int J Cancer. 1981 Mar 15;27(3):273-80. doi: 10.1002/ijc.2910270304.
7
Lysis of fresh human tumour cells by autologous tumour-associated lymphocytes: two distinct types of autologous tumour killer cells induced by co-culture with autologous tumour.自体肿瘤相关淋巴细胞对新鲜人肿瘤细胞的裂解作用：与自体肿瘤共培养诱导出两种不同类型的自体肿瘤杀伤细胞。
Cancer Immunol Immunother. 1985;20(1):29-37. doi: 10.1007/BF00199770.
8
Auto-tumor lysis by blood lymphocytes in vitro. Strongly activated lymphocytes lack selectivity.体外血液淋巴细胞的自动肿瘤溶解。强烈激活的淋巴细胞缺乏选择性。
Cancer Immunol Immunother. 1989;29(2):125-32. doi: 10.1007/BF00199287.
9
Tumour-reactive lymphocytes stimulated in mixed lymphocyte and tumour culture. Clonal analysis of effector cells in cytotoxic and proliferative assays.在混合淋巴细胞与肿瘤培养中刺激产生的肿瘤反应性淋巴细胞。细胞毒性和增殖试验中效应细胞的克隆分析。
Cancer Immunol Immunother. 1983;15(3):227-36. doi: 10.1007/BF00199170.
10
MHC class-I-restricted auto-tumor-specific CD4+CD8- T-cell clones established from autologous mixed lymphocyte-tumor-cell culture (MLTC).从自体混合淋巴细胞-肿瘤细胞培养（MLTC）中建立的MHC I类限制性自身肿瘤特异性CD4+CD8-T细胞克隆。
Int J Cancer. 1992 Jul 30;51(6):962-7. doi: 10.1002/ijc.2910510621.

本文引用的文献

1
Lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with lectins.用凝集素体外激活的自体淋巴细胞对新鲜人实体瘤的溶解作用。
Cancer Res. 1982 Mar;42(3):913-8.
2
Induction of cytotoxic activity in human lymphocytes against autologous and allogeneic melanoma cells in vitro by culture with interleukin 2.通过与白细胞介素-2共同培养，在体外诱导人淋巴细胞对自体和同种异体黑色素瘤细胞产生细胞毒性活性。
Int J Cancer. 1981 Dec;28(6):695-703. doi: 10.1002/ijc.2910280607.
3
Lysis of autologous human melanoma cells by in vitro allosensitized peripheral blood lymphocytes.体外同种致敏外周血淋巴细胞对自体人黑色素瘤细胞的裂解作用。
Cancer Immunol Immunother. 1982;14(2):99-104. doi: 10.1007/BF00200176.
4
Correlation between lymphocyte-mediated auto-tumor reactivities and the clinical course. II. Evaluation of 69 patients with lung carcinoma.淋巴细胞介导的自身肿瘤反应性与临床病程的相关性。II. 69例肺癌患者的评估
Cancer Immunol Immunother. 1983;16(1):17-22. doi: 10.1007/BF00199900.
5
Correlation between lymphocyte-mediated auto-tumor reactivities and clinical course. I. Evaluation of 46 patients with sarcoma.淋巴细胞介导的自身肿瘤反应性与临床病程的相关性。I. 46例肉瘤患者的评估
Cancer Immunol Immunother. 1983;16(1):11-6. doi: 10.1007/BF00199899.
6
Lysis of tumor biopsy cells by autologous T lymphocytes activated in mixed cultures and propagated with T cell growth factor.通过在混合培养物中激活并与T细胞生长因子一起增殖的自体T淋巴细胞对肿瘤活检细胞进行裂解。
J Exp Med. 1982 Jan 1;155(1):83-95. doi: 10.1084/jem.155.1.83.
7
Tumor biopsy cells participating in systems in which cytotoxicity of lymphocytes is generated. Autologous and allogeneic studies.参与淋巴细胞细胞毒性产生系统的肿瘤活检细胞。自体和异体研究。
Int J Cancer. 1981 Mar 15;27(3):273-80. doi: 10.1002/ijc.2910270304.
8
Clonotypic surface structure on human T lymphocytes: functional and biochemical analysis of the antigen receptor complex.人类T淋巴细胞上的克隆型表面结构：抗原受体复合物的功能与生化分析
Immunol Rev. 1984 Oct;81:95-129. doi: 10.1111/j.1600-065x.1984.tb01106.x.
9
Specificity of auto-tumor cytotoxicity exerted by fresh, activated and propagated human T lymphocytes.新鲜、活化及增殖的人T淋巴细胞产生的自身肿瘤细胞毒性的特异性
Int J Cancer. 1982 May 15;29(5):547-53. doi: 10.1002/ijc.2910290510.
10
Antigen recognition: the specificity of T cells involved in the cellular immune response.抗原识别：参与细胞免疫应答的T细胞的特异性。
Transplant Rev. 1972;10:97-111. doi: 10.1111/j.1600-065x.1972.tb01540.x.

自体混合淋巴细胞肿瘤细胞培养中激活的血液淋巴细胞对自体肿瘤细胞的溶解作用——与术后临床病程无关。

Lysis of autologous tumor cells by blood lymphocytes activated in autologous mixed lymphocyte tumor cell culture--no correlation with the postsurgical clinical course.

作者信息

Vánky F, Klein E, Willems J, Böök K, Ivert T, Péterffy A, Nilsonne U, Kreicbergs A

出版信息

Cancer Immunol Immunother. 1987;24(2):180-3. doi: 10.1007/BF00205598.

DOI:10.1007/BF00205598
PMID:2950997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038937/
Abstract

Mixed lymphocyte tumor cell cultures (MLTC) were initiated with cells collected at the time of surgery from 62 patients with the following diagnoses: 12 squamous cell carcinoma, 14 adenocarcinoma of the lung, 17 osteosarcomas, and 16 soft tissue sarcomas. The lytic effect generated against autologous tumor cells was tested on the 7th day. These patients had been part of previous evaluation, which revealed that the lysis of autologous tumor cells by freshly collected lymphocytes correlated with the postsurgical clinical course. Patients with long survival exhibited autotumor lysis without previous activation. Blood lymphocytes of about half of the primarily nonreactive patients were stimulated for lytic function in MLTC. However, this parameter showed no correlation with the clinical course.

摘要

混合淋巴细胞肿瘤细胞培养（MLTC）始于从62例患者手术时采集的细胞，这些患者的诊断如下：12例鳞状细胞癌、14例肺腺癌、17例骨肉瘤和16例软组织肉瘤。在第7天测试针对自体肿瘤细胞产生的裂解效应。这些患者曾参与先前的评估，该评估显示新鲜采集的淋巴细胞对自体肿瘤细胞的裂解与术后临床病程相关。长期存活的患者在未预先激活的情况下表现出自体肿瘤裂解。约一半最初无反应患者的血液淋巴细胞在MLTC中被刺激发挥裂解功能。然而，该参数与临床病程无相关性。