自体混合淋巴细胞肿瘤细胞培养中激活的血液淋巴细胞对自体肿瘤细胞的溶解作用——与术后临床病程无关。
Lysis of autologous tumor cells by blood lymphocytes activated in autologous mixed lymphocyte tumor cell culture--no correlation with the postsurgical clinical course.
作者信息
Vánky F, Klein E, Willems J, Böök K, Ivert T, Péterffy A, Nilsonne U, Kreicbergs A
出版信息
Cancer Immunol Immunother. 1987;24(2):180-3. doi: 10.1007/BF00205598.
Mixed lymphocyte tumor cell cultures (MLTC) were initiated with cells collected at the time of surgery from 62 patients with the following diagnoses: 12 squamous cell carcinoma, 14 adenocarcinoma of the lung, 17 osteosarcomas, and 16 soft tissue sarcomas. The lytic effect generated against autologous tumor cells was tested on the 7th day. These patients had been part of previous evaluation, which revealed that the lysis of autologous tumor cells by freshly collected lymphocytes correlated with the postsurgical clinical course. Patients with long survival exhibited autotumor lysis without previous activation. Blood lymphocytes of about half of the primarily nonreactive patients were stimulated for lytic function in MLTC. However, this parameter showed no correlation with the clinical course.
混合淋巴细胞肿瘤细胞培养（MLTC）始于从62例患者手术时采集的细胞，这些患者的诊断如下：12例鳞状细胞癌、14例肺腺癌、17例骨肉瘤和16例软组织肉瘤。在第7天测试针对自体肿瘤细胞产生的裂解效应。这些患者曾参与先前的评估，该评估显示新鲜采集的淋巴细胞对自体肿瘤细胞的裂解与术后临床病程相关。长期存活的患者在未预先激活的情况下表现出自体肿瘤裂解。约一半最初无反应患者的血液淋巴细胞在MLTC中被刺激发挥裂解功能。然而，该参数与临床病程无相关性。
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