淋巴细胞介导的自身肿瘤反应性与临床病程的相关性。II. 69例肺癌患者的评估
Correlation between lymphocyte-mediated auto-tumor reactivities and the clinical course. II. Evaluation of 69 patients with lung carcinoma.
作者信息
Vánky F, Péterffy A, Böök K, Willems J, Klein E, Klein G
出版信息
Cancer Immunol Immunother. 1983;16(1):17-22. doi: 10.1007/BF00199900.
Abstract
T-cell-enriched lymphocyte populations of 69 lung carcinoma (44 squamous cell, 23 adeno-, and two large cell carcinoma) patients were investigated at the time of surgery for proliferative response to, and/or cytotoxic potential against, freshly separated autologous tumor cells. Tumor-free period and survival time of the patients were correlated with the reactivity obtained in the in vitro tests. The observation time varied between 20 and 78 months (mean 52). Tumor-free period and survival time were longer and survival rate higher in the group with lymphocyte reactivity toward their tumors. In the non-reactive group, all patients but one died within 3 years. Almost all patients had cytotoxic lymphocytes against K562, the three who did not belonging to the category with short survival time.
摘要
在手术时，对69例肺癌患者（44例鳞状细胞癌、23例腺癌和2例大细胞癌）富含T细胞的淋巴细胞群体进行了研究，以检测其对新鲜分离的自体肿瘤细胞的增殖反应和/或细胞毒性潜力。将患者的无瘤期和生存时间与体外试验中获得的反应性进行关联。观察时间在20至78个月之间（平均52个月）。淋巴细胞对其肿瘤有反应性的组，无瘤期和生存时间更长，生存率更高。在无反应性组中，除1例患者外，所有患者均在3年内死亡。几乎所有患者都有针对K562的细胞毒性淋巴细胞，未产生此类细胞毒性淋巴细胞的3例患者生存期较短。
相似文献
1
Correlation between lymphocyte-mediated auto-tumor reactivities and the clinical course. II. Evaluation of 69 patients with lung carcinoma.淋巴细胞介导的自身肿瘤反应性与临床病程的相关性。II. 69例肺癌患者的评估
Cancer Immunol Immunother. 1983;16(1):17-22. doi: 10.1007/BF00199900.
2
Correlation between lymphocyte-mediated auto-tumor reactivities and clinical course. I. Evaluation of 46 patients with sarcoma.淋巴细胞介导的自身肿瘤反应性与临床病程的相关性。I. 46例肉瘤患者的评估
Cancer Immunol Immunother. 1983;16(1):11-6. doi: 10.1007/BF00199899.
3
Lysis of fresh human tumour cells by autologous tumour-associated lymphocytes: two distinct types of autologous tumour killer cells induced by co-culture with autologous tumour.自体肿瘤相关淋巴细胞对新鲜人肿瘤细胞的裂解作用：与自体肿瘤共培养诱导出两种不同类型的自体肿瘤杀伤细胞。
Cancer Immunol Immunother. 1985;20(1):29-37. doi: 10.1007/BF00199770.
4
5
Lysis of autologous tumor cells by blood lymphocytes tested at the time of surgery. Correlation with the postsurgical clinical course.手术时检测血液淋巴细胞对自体肿瘤细胞的溶解作用。与术后临床病程的相关性。
Cancer Immunol Immunother. 1986;21(1):69-76. doi: 10.1007/BF00199380.
6
[Cytotoxicity of lymphocytes against autologous cultured primary lung cancer cells in relation to histological type and clinical stage].淋巴细胞对自体培养原发性肺癌细胞的细胞毒性与组织学类型和临床分期的关系
Gan To Kagaku Ryoho. 1986 Jun;13(6):2175-81.
7
Suppression of T-cell response in autologous mixed lymphocyte-tumor culture by large granular lymphocytes.大颗粒淋巴细胞对自体混合淋巴细胞-肿瘤培养中T细胞反应的抑制作用。
J Natl Cancer Inst. 1986 Mar;76(3):389-98.
8
Autologous mixed lymphocyte-tumor reaction and autologous mixed lymphocyte reaction. II. Generation of specific and non-specific killer T cells capable of lysing autologous tumor.自体混合淋巴细胞-肿瘤反应和自体混合淋巴细胞反应。II. 能够裂解自体肿瘤的特异性和非特异性杀伤性T细胞的产生。
Int J Cancer. 1988 May 15;41(5):651-6. doi: 10.1002/ijc.2910410502.
9
Importance of MHC antigen expression on solid tumors in the in vitro interaction with autologous blood lymphocytes.主要组织相容性复合体（MHC）抗原在实体瘤上的表达在其与自体血淋巴细胞的体外相互作用中的重要性。
Cancer Immunol Immunother. 1988;27(3):213-22. doi: 10.1007/BF00205442.
10
Specific T-cell-mediated killing of autologous lung tumour cells.特异性T细胞介导的自体肺肿瘤细胞杀伤作用。
Cell Immunol. 1980 Sep 15;55(1):12-9. doi: 10.1016/0008-8749(80)90132-x.
引用本文的文献
1
Biological significance of autologous tumor-killing activity and its induction therapy.自体肿瘤杀伤活性的生物学意义及其诱导治疗
Cancer Immunol Immunother. 1993 Jul;37(2):75-83. doi: 10.1007/BF01517038.
2
Distribution of histocompatibility and leucocyte differentiation antigens in normal human colon and in benign and malignant colonic neoplasms.组织相容性和白细胞分化抗原在正常人类结肠以及良性和恶性结肠肿瘤中的分布。
Br J Cancer. 1984 Nov;50(5):699-709. doi: 10.1038/bjc.1984.239.
3
Autologous cellular immune response to primary and metastatic human melanomas and its regulation by DR antigens expressed on tumor cells.针对原发性和转移性人类黑色素瘤的自体细胞免疫反应及其受肿瘤细胞上表达的DR抗原的调节。
Cancer Metastasis Rev. 1985;4(1):7-26. doi: 10.1007/BF00047734.
4
DR antigens expressed on tumor cells do not contribute to the blastogenetic response of autologous T cells.肿瘤细胞上表达的DR抗原对自体T细胞的母细胞生成反应没有作用。
Cancer Immunol Immunother. 1985;19(3):219-25. doi: 10.1007/BF00199230.
5
Activation of lymphocyte anti-tumour responses in man: effector heterogeneity and the search for immunomodulators.人类淋巴细胞抗肿瘤反应的激活：效应细胞异质性与免疫调节剂的探索。
Cancer Metastasis Rev. 1987;5(4):299-312. doi: 10.1007/BF00055375.
6
In vitro generation of tumour-specific lymphocyte reactivity to colonic carcinoma cells. Comparison with normal colonic mucosa cells.体外产生对结肠癌细胞的肿瘤特异性淋巴细胞反应。与正常结肠黏膜细胞的比较。
Cancer Immunol Immunother. 1987;25(3):209-14. doi: 10.1007/BF00199149.
7
Tumor-derived interleukin-2-dependent lymphocytes in adoptive immunotherapy of lung cancer.肿瘤衍生的白细胞介素-2依赖淋巴细胞在肺癌过继性免疫治疗中的应用
Cancer Immunol Immunother. 1987;24(1):76-85. doi: 10.1007/BF00199837.
8
Lysis of autologous tumor cells by blood lymphocytes tested at the time of surgery. Correlation with the postsurgical clinical course.手术时检测血液淋巴细胞对自体肿瘤细胞的溶解作用。与术后临床病程的相关性。
Cancer Immunol Immunother. 1986;21(1):69-76. doi: 10.1007/BF00199380.
9
Tumour volume and macroscopic growth pattern of bronchogenic carcinoma.支气管源性癌的肿瘤体积和大体生长模式。
Virchows Arch A Pathol Anat Histopathol. 1985;405(3):387-97. doi: 10.1007/BF00710073.
10
Proliferative response of lymphocytes from ovarian cancer patients to autologous tumor cells.卵巢癌患者淋巴细胞对自体肿瘤细胞的增殖反应。
Cancer Immunol Immunother. 1988;27(1):69-76. doi: 10.1007/BF00205761.
本文引用的文献
1
Evaluation of the long-term results of surgery for bronchial carcinoma.支气管癌手术的长期效果评估。
J Thorac Cardiovasc Surg. 1981 Sep;82(3):325-33.
2
Specific and non-specific lymphocyte cytotoxicity in colon carcinoma.结肠癌中的特异性和非特异性淋巴细胞细胞毒性
Br J Cancer. 1981 Dec;44(6):846-55. doi: 10.1038/bjc.1981.283.
3
Long-term survival and cure in lung cancer surgery.
Thorac Cardiovasc Surg. 1982 Oct;30(5):292-3. doi: 10.1055/s-2007-1022409.
4
Frequency of residual and metastatic tumor in patients undergoing curative surgical resection for lung cancer.接受肺癌根治性手术切除患者的残留和转移瘤发生率
Cancer Chemother Rep 3. 1973 Mar;4(2):63-7.
5
Study of the tumor cell-lymphocyte interaction in patients with breast cancer.乳腺癌患者肿瘤细胞与淋巴细胞相互作用的研究。
Cancer. 1972 May;29(5):1321-5. doi: 10.1002/1097-0142(197205)29:5<1321::aid-cncr2820290529>3.0.co;2-m.
6
Human tumor-lymphocyte interaction in vitro. III. T lymphocytes in autologous tumor stimulation (ATS).
Int J Cancer. 1978 Dec;22(6):679-86. doi: 10.1002/ijc.2910220607.
7
Human tumor-lymphocyte interaction in vitro. VI. Specificity of primary and secondary autologous lymphocyte-mediated cytotoxicity.
J Natl Cancer Inst. 1979 Jun;62(6):1407-13.
8
Restricted autologous lymphocytotoxicity in lung neoplasia.肺癌中的自体淋巴细胞毒性受限
Br J Cancer. 1978 Sep;38(3):375-81. doi: 10.1038/bjc.1978.217.
Zotero 插件