Department of Haemaotology/Oncology, University Medicine Greifswald, Greifswald, Germany.
Department of Urology and Paediatric Urology, Westpfalz-Hospital, Kaiserslautern, Germany.
Eur J Haematol. 2018 Jun;100(6):584-591. doi: 10.1111/ejh.13052. Epub 2018 Apr 6.
There is a substantial lack of data about men`s health in adult allogeneic stem cell transplantation.
We conducted prospective unicentric non-interventional clinical study on men's health with a follow-up time of 1 year.
Between 11/2013 and 12/2015, we were able to include 27 patients. AML was the most frequent underlying disease (25.9%), and we mainly used intermediate intense conditioning protocols (77.8%). Erectile dysfunction, loss of libido, and loss of efficiency were the most frequent symptoms of hypogonadism. At inclusion of the study, hypogonadism was already frequent. Primary hypogonadism was found in eight cases (29.6%) and secondary hypogonadism in one case (3.7%). We did not observe hypogonadism 6 months after inpatient treatment anymore, but there might still be the impairment of fertility because of still rising FSH levels at the end of the observation period. There were no significant associations of hypogonadism with myeloablative conditioning or kind of donor. Interestingly, there is a significant association with nicotine abuse (P = .049).
On the whole, male hypogonadism was found in one-third of the patients who underwent allogeneic stem cell transplantation.
成人异基因造血干细胞移植中男性健康数据严重缺乏。
我们进行了一项前瞻性、单中心、非干预性的男性健康临床研究，随访时间为 1 年。
在 2013 年 11 月至 2015 年 12 月期间，我们共纳入 27 例患者。最常见的基础疾病是急性髓细胞白血病（AML，25.9%），我们主要使用中等强度的预处理方案（77.8%）。勃起功能障碍、性欲减退和效率下降是性腺功能减退最常见的症状。在研究纳入时，已经存在性腺功能减退。原发性性腺功能减退 8 例（29.6%），继发性性腺功能减退 1 例（3.7%）。我们在住院治疗后 6 个月不再观察到性腺功能减退，但由于在观察期末 FSH 水平仍升高，可能仍存在生育能力受损。性腺功能减退与清髓性预处理或供者类型无显著相关性。有趣的是，它与尼古丁滥用显著相关（P=0.049）。
在接受异基因造血干细胞移植的患者中，三分之一存在男性性腺功能减退。
