Department of Neuropsychiatry, Toho University School of Medicine, 6-11-1 Omori-nishi, Ota-ku, Tokyo 143-8541, Japan.
Department of Neuropsychiatry, Toho University School of Medicine, 6-11-1 Omori-nishi, Ota-ku, Tokyo 143-8541, Japan; Department of Medical Affairs, Otsuka Pharmaceutical Co., Ltd., Shinagawa Grand Central Tower, 2-16-4 Konan, Minato-ku, Tokyo 108-8242, Japan.
Psychiatry Res. 2018 May;263:94-100. doi: 10.1016/j.psychres.2018.02.038. Epub 2018 Feb 20.
Social anxiety is commonly reported as a comorbid condition among people with schizophrenia. The aims of this study were to elucidate the associations between demographic/clinical features and social anxiety. A total of 207 outpatients with schizophrenia underwent assessments for social anxiety, psychiatric symptoms, social cognition, cognitive function, social functioning, and quality of life (QOL). To confirm the prediction model for social anxiety, we conducted multiple linear regressions using the Liebowitz Social Anxiety Scale (LSAS) score as an outcome variable and demographic/clinical variables as predictors. Of the 207 patients, 30 (14.5%) met the criteria for social anxiety disorder and 109 (52.7%) had a mean LSAS score higher than 30, suggesting that their social anxiety symptoms had reached a clinical level. Social anxiety was significantly correlated with psychiatric symptoms, social functioning, and QOL, whereas significant correlations with social cognition and cognitive function were not observed. A multiple regression analysis identified social functioning, gender, age of onset, and duration of untreated psychosis (DUP) as predictors that were most closely associated with the LSAS score. We confirmed that social anxiety symptoms were highly prevalent among outpatients with schizophrenia and were closely associated with social functioning and DUP, rather than social cognitive impairments.
社交焦虑症在精神分裂症患者中常被报告为共病状态。本研究旨在阐明人口统计学/临床特征与社交焦虑之间的关联。共有 207 名精神分裂症门诊患者接受了社交焦虑、精神症状、社会认知、认知功能、社会功能和生活质量（QOL）评估。为了确认社交焦虑的预测模型，我们使用 Liebowitz 社交焦虑量表（LSAS）评分作为因变量，人口统计学/临床变量作为预测因子，进行了多元线性回归分析。在 207 名患者中，有 30 名（14.5%）符合社交焦虑障碍的标准，109 名（52.7%）的 LSAS 评分高于 30，表明他们的社交焦虑症状已达到临床水平。社交焦虑与精神症状、社会功能和生活质量显著相关，而与社会认知和认知功能无显著相关。多元回归分析确定社会功能、性别、发病年龄和未治疗精神病持续时间（DUP）是与 LSAS 评分最密切相关的预测因子。我们证实，社交焦虑症状在精神分裂症门诊患者中高度普遍，与社会功能和 DUP 密切相关，而与社会认知障碍无关。
