Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei 430022, China.
Zool Res. 2018 Jan 18;39(1):25-31. doi: 10.24272/j.issn.2095-8137.2018.013.
Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus (HBV) worldwide. Current antiviral therapies, including interferon and nucleot(s)ide analogues, rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathogenesis of chronic hepatitis B and developing new therapeutic drugs or strategies. HBV can only infect humans and chimpanzees, with the use of chimpanzees in HBV research strongly restricted. Thus, most advances in HBV research have been gained using mouse models with HBV replication or infection or models with HBV-related hepadnaviral infection. This review summarizes the animal models currently available for the study of HBV infection.
即使有有效的疫苗，估计全世界仍有 2.4 亿人慢性感染乙型肝炎病毒 (HBV)。目前的抗病毒疗法，包括干扰素和核苷（酸）类似物，很少能治愈慢性乙型肝炎。动物模型对于理解慢性乙型肝炎的发病机制和开发新的治疗药物或策略非常重要。HBV 只能感染人类和黑猩猩，黑猩猩在 HBV 研究中的使用受到严格限制。因此，HBV 研究的大部分进展都是使用具有 HBV 复制或感染的小鼠模型或具有 HBV 相关肝病毒感染的模型获得的。本综述总结了目前用于研究 HBV 感染的动物模型。
