空腹血糖与冠心病、中风及全因死亡率风险：对1913年出生男性的17年随访研究

Fasting blood glucose and risk of coronary heart disease, stroke, and all-cause mortality: a 17-year follow-up study of men born in 1913.

作者信息

Ohlson L O, Svärdsudd K, Welin L, Eriksson H, Wilhelmsen L, Tibblin G, Larsson B

出版信息

Diabet Med. 1986 Jan;3(1):33-7. doi: 10.1111/j.1464-5491.1986.tb00702.x.

DOI:10.1111/j.1464-5491.1986.tb00702.x

Abstract

This report concerns the relationship between baseline levels of fasting blood glucose (FBG) in non-diabetics and the subsequent 17-year incidence of coronary heart disease (CHD), stroke and all-cause mortality. In 1963, 973 men aged 50 years were recruited from a general Swedish urban population for a prospective study of risk factors for CHD. Eight hundred and fifty-five (88%) men agreed to participate and have been observed for 17 years. The 832 men who had no history of myocardial infarction, stroke, diabetes mellitus or who had a fasting blood glucose below 7.0 mmol/l at baseline were selected for this analysis. CHD occurred in 106 men, 35 developed a stroke and 137 died during follow-up. When quintiles and deciles of the FBG distribution were considered, no trend of 17-year incidence of CHD, stroke or death was apparent. However, for men with an FBG above the 95th percentile (greater than 5.7 mmol/l) a non-significant trend towards increasing risk was indicated.

摘要

本报告关注非糖尿病患者空腹血糖（FBG）基线水平与随后17年冠心病（CHD）、中风及全因死亡率之间的关系。1963年，从瑞典城市普通人群中招募了973名50岁男性，对冠心病风险因素进行前瞻性研究。855名（88%）男性同意参与并接受了17年的观察。本分析选取了832名无心肌梗死、中风、糖尿病病史且基线空腹血糖低于7.0 mmol/l的男性。随访期间，106名男性发生冠心病，35名患中风，137名死亡。当考虑FBG分布的五分位数和十分位数时，CHD、中风或死亡的17年发病率无明显趋势。然而，对于FBG高于第95百分位数（大于5.7 mmol/l）的男性，显示出风险增加的非显著趋势。