Şefik Ertuğrul, Günlüsoy Bülent, Aydoğdu Özgü, Topçu Yusuf Kadir, Ceylan Yasin, Değirmenci Tansu, Dinçel Çetin
Clinic of Urology, İzmir Training and Research Hospital, İzmir, Turkey.
Turk J Urol. 2018 Mar;44(2):119-124. doi: 10.5152/tud.2017.46038. Epub 2018 Mar 1.
The aim of this study is to examine the usefulness of preoperative neutrophile-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratios to predict pathological upstaging of invasive bladder cancer who underwent radical cystectomy.
A total of 126 patients who underwent radical cystectomy at our clinic between January 2006 and March 2015 were retrospectively analysed. One hundred and twelve patients with organ-confined invasive bladder tumors (T2) detected at histopathological examination of transuretral resection material were included in the study. Upstaging was seen at histopathological examination of radical cystectomy specimens of 42 patients. We compared preoperative neutrophile-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio between upstaged and not-upstaged groups.
There were no statistically significant correlation between age, time to radical cystectomy, gender, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio ratios and carcinoma in situ in upstaged and non-upstaged groups. Statistical analyses showed that preoperative neutrophile-to-lymphocyte ratio was higher in upstaged patients (p=0.009). In multivariate analysis preoperative neutrophile-to-lymphocyte ratio and positive surgical margin were significantly higher in upstaged group.
In organ-confined muscle invasive bladder cancer neutrophile-to-lymphocyte ratio seems to be an acceptable parameter to predict locally advanced disease.
本研究旨在探讨术前中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值以及淋巴细胞与单核细胞比值对接受根治性膀胱切除术的浸润性膀胱癌病理分期上调的预测价值。
回顾性分析2006年1月至2015年3月期间在我院接受根治性膀胱切除术的126例患者。本研究纳入了112例经尿道切除组织病理检查发现为器官局限性浸润性膀胱肿瘤（T2）的患者。42例患者在根治性膀胱切除标本的病理检查中出现分期上调。我们比较了分期上调组和未分期上调组术前的中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值、淋巴细胞与单核细胞比值。
分期上调组和未分期上调组在年龄、至根治性膀胱切除术的时间、性别、淋巴细胞与单核细胞比值、血小板与淋巴细胞比值以及原位癌方面均无统计学显著相关性。统计分析表明，分期上调患者的术前中性粒细胞与淋巴细胞比值较高（p = 0.009）。多因素分析显示，分期上调组的术前中性粒细胞与淋巴细胞比值和手术切缘阳性率显著更高。
在器官局限性肌肉浸润性膀胱癌中，中性粒细胞与淋巴细胞比值似乎是预测局部晚期疾病的一个可接受参数。
