异基因造血干细胞移植后因免疫球蛋白G2亚类缺乏导致的复发性细菌性肺炎：免疫球蛋白替代治疗的疗效
Recurrent bacterial pneumonia due to immunoglobulin G2 subclass deficiency after allogeneic hematopoietic stem cell transplantation: Efficacy of immunoglobulin replacement.
作者信息
Yamazaki Rie, Kikuchi Taku, Kato Jun, Sakurai Masatoshi, Koda Yuya, Hashida Risa, Yamane Yusuke, Abe Ryohei, Hasegawa Naoki, Okamoto Shinichiro, Mori Takehiko
机构信息
Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Center for Infectious Diseases and Infection Control, Keio University School of Medicine, Tokyo, Japan.
出版信息
Transpl Infect Dis. 2018 Jun;20(3):e12863. doi: 10.1111/tid.12863. Epub 2018 Mar 25.
Immunoglobulin (Ig) G2 subclass deficiency is known to be associated with recurrent bacterial respiratory infections caused by capsulated bacteria. We encountered a case of recurrent pneumonia due to Streptococcus pneumoniae after allogeneic hematopoietic stem cell transplantation (HSCT). IgG2 subclass level was specifically low, and prophylactic Ig replacement successfully prevented subsequent infections. However, the cessation of Ig replacement resulted in subsequent pneumonia. These findings suggested that IgG2 deficiency could be a cause of recurrent pneumococcal infection after allogeneic HSCT.
已知免疫球蛋白（Ig）G2亚类缺乏与由包膜细菌引起的复发性细菌性呼吸道感染有关。我们遇到了一例异基因造血干细胞移植（HSCT）后因肺炎链球菌导致复发性肺炎的病例。IgG2亚类水平特别低，预防性Ig替代成功预防了随后的感染。然而，Ig替代的停止导致了随后的肺炎。这些发现表明，IgG2缺乏可能是异基因HSCT后复发性肺炎球菌感染的一个原因。
Zotero 插件