亚硝酸盐作为一种药物干预手段用于成功治疗挤压综合征。
Nitrite as a pharmacological intervention for the successful treatment of crush syndrome.
作者信息
Kobayashi Jun, Murata Isamu
机构信息
Division of Pathophysiology, Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Science, Josai University, Saitama, Japan.
Division of Drug Safety Management, Faculty of Pharmacy and Pharmaceutical Science, Josai University, Saitama, Japan.
出版信息
Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13633.
Abstract
Crush syndrome is characterized by ischemia/reperfusion injury (IRI). The protective effect of nitrite on experimentally induced IRI has been demonstrated in the heart, kidney, liver, and skeletal muscle. IRI in tissues and systemic organs occurs due to the massive generation of reactive oxygen species and subsequent systemic inflammation. Therefore, ischemic pre and postconditioning are performed in clinical practice. Intravenous administration of nitrite inhibits IRI through nitric oxide-mediated mechanisms. In this paper, we discuss the utility of nitrite as a pharmacological postconditioning agent in the treatment of crush syndrome.
摘要
挤压综合征的特征是缺血/再灌注损伤（IRI）。亚硝酸盐对实验诱导的IRI的保护作用已在心脏、肾脏、肝脏和骨骼肌中得到证实。组织和全身器官中的IRI是由于活性氧的大量产生以及随后的全身炎症反应所致。因此，缺血预处理和后处理在临床实践中得以应用。静脉注射亚硝酸盐通过一氧化氮介导的机制抑制IRI。在本文中，我们讨论了亚硝酸盐作为一种药理学后处理剂在挤压综合征治疗中的效用。
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